USE OF PURIFIED ANTRODIA CINNAMOMEA EXTRACT

Title:

USE OF PURIFIED ANTRODIA CINNAMOMEA EXTRACT

Document Type and Number:

WIPO Patent Application WO/2017/201994

Kind Code:

A1

Abstract:

A purified dehydroeburicoic acid extracted from an Antrodia cinnamomea and use thereof in anti-type 2 diabetic, anti-hypertriglyceridemic, and anti-hypercholesterolemic applications, and for lowering liver fat accumulation. The purified compound is a dehydroeburicoic acid (TT) extracted from an Antrodia cinnamomea mycelium. Measurements of increased expressions of a glucose transporter 4 (GLUT4) in skeletal muscle cell membrane, peroxisome proliferator-activated receptor α (PPARα) in liver, and phospho-AMP-activated protein kinase (p-AMPK) in skeletal muscle and liver, and of decreased expressions of fatty acid synthase (FAS) and peroxisome proliferator-activated receptor γ (PPARγ) in liver demonstrated that the dehydroeburicoic acid (TT) has anti-type 2 diabetic and anti-dyslipidemic applications in medical settings.

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Inventors:

SHIH CHUN-CHING (CN)
KUO YUEH-HSIUNG (CN)
LIN CHENG-HSIU (CN)

Application Number:

PCT/CN2016/107285

Publication Date:

November 30, 2017

Filing Date:

November 28, 2016

Export Citation:

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Assignee:

SHIH CHUN-CHING (CN)

International Classes:

A61K31/575; A61P3/06; A61P3/10

Foreign References:

JPH10330266A	1998-12-15
CN104606260A	2015-05-13

Other References:

KUO, Y.H. ET AL.: "Antidiabetic and Antihyperlipidemic Properties of a Triterpenoid Compound, Dehydroeburicoic Acid, from Antrodia camphorata in Vitro and in Streptozotocin-Induced Mice", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 63, 27 October 2015 (2015-10-27), pages 10140 - 10151, XP055441608
SATO, M. ET AL.: "Dehydrotrametenolic Acid Induces Preadipocyte Differentiation and Sensitizes Animal Models of Noninsulin-Dependent Diabetes Mellitus to Insulin", BIOL. PHARM. BULL., vol. 25, no. 1, 31 December 2002 (2002-12-31), pages 81 - 86, XP002605337

Attorney, Agent or Firm:

NTD PATENT & TRADEMARK AGENCY LIMITED (CN)

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