Title:
THE USE OF SUBSTITUTED AZETIDINONE COMPOUNDS FOR THE TREATMENT OF SITOSTEROLEMIA
Document Type and Number:
WIPO Patent Application WO2002058696
Kind Code:
A3
Abstract:
The present invention is directed to the use of sterol absorption inhibiting compounds, pharmaceutical compositions thereof, therapeutic combinations and their use in combination with other lipid lowering agents to treat or prevent sitosterolemia and/or to lower the concentration of sterol(s) other than cholesterol in plasma or tissue of a mammal. Methods of treating or preventing vascular disease and coronary events also are provided.
Inventors:
DAVIS HARRY R
Application Number:
PCT/US2002/001195
Publication Date:
March 13, 2003
Filing Date:
January 25, 2002
Export Citation:
Assignee:
SCHERING CORP (US)
International Classes:
C07D205/08; A61K31/397; A61K31/7042; A61K45/00; A61K45/06; A61P3/06; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P43/00; (IPC1-7): A61K31/397; A61P3/06; A61P9/10
Domestic Patent References:
| WO1996019450A1 | 1996-06-27 | |||
| WO1997016455A1 | 1997-05-09 |
Foreign References:
| US5846966A | 1998-12-08 | |||
| US5624920A | 1997-04-29 | |||
| US5698548A | 1997-12-16 | |||
| US5688990A | 1997-11-18 | |||
| EP0524595A1 | 1993-01-27 |
Other References:
DATABASE MEDLINE [online] December 1990 (1990-12-01), BELAMARICH P F ET AL: "Response to diet and cholestyramine in a patient with sitosterolemia.", XP002222942, Database accession no. NLM2251034
DATABASE MEDLINE [online] September 1985 (1985-09-01), SALEN G ET AL: "Lethal atherosclerosis associated with abnormal plasma and tissue sterol composition in sitosterolemia with xanthomatosis.", XP002222944, Database accession no. NLM4067433
DATABASE MEDLINE [online] September 1985 (1985-09-01), SALEN G ET AL: "Lethal atherosclerosis associated with abnormal plasma and tissue sterol composition in sitosterolemia with xanthomatosis.", XP002222944, Database accession no. NLM4067433
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