VACCINE AND ANTITOXIN FOR TREATMENT AND PREVENTION OF C. DIFFICILE DISEASE

WIPO Patent Application WO1996012802

A9

The present invention provides neutralizing antitoxin directed against C. difficile toxins. These antitoxins are produced in avian species using soluble recombinant C. difficile toxin proteins. The avian antitoxins are designed so as to be orally administrable in therapeutic amounts and may be in any form (i.e., as a solid or in aqueous solution). Solid forms of the antitoxin may comprise an enteric coating. These antitoxins are useful in the treatment of humans and other animals intoxicated with at least one bacterial toxin. The invention further provides vaccines capable of protecting a vaccinated recipient from the morbidity and mortality associated with C. difficile infection. These vaccines are useful for administration to humans and other animals at risk of exposure to C. difficile toxins.

WILLIAMS JAMES A (US)
PADHYE NISHA V (US)
KINK JOHN A (US)
THALLEY BRUCE S (US)
STAFFORD DOUGLAS C (US)
FIRCA JOSEPH R (US)

PCT/US1995/013737

September 16, 1999

October 23, 1995

Click for automatic bibliography generation  

OPHIDIAN PHARM INC (US)
WILLIAMS JAMES A (US)
PADHYE NISHA V (US)
KINK JOHN A (US)
THALLEY BRUCE S (US)
STAFFORD DOUGLAS C (US)
FIRCA JOSEPH R (US)

C12N15/09; A61K9/28; A61K38/00; A61K39/08; A61K39/395; A61K39/40; A61K47/10; A61P31/04; C07K1/16; C07K1/22; C07K14/245; C07K14/33; C07K14/38; C07K16/00; C07K16/02; C07K16/06; C07K16/12; C07K16/18; C07K17/08; C07K19/00; C12N1/20; C12N1/21; C12N15/00; C12N15/13; C12N15/31; C12P21/08; G01N33/53; G01N33/543; G01N33/546; G01N33/569; A61K39/00; C12N; (IPC1-7): C12N15/00; C12N15/13; C12N1/20; G01N33/569; A61K39/40; C07K16/00; C07K16/12; C07K1/16; C07K14/33; C07K19/00

View/Download PDF      PDF Help

Previous Patent: ORAL IMMUNIZATION WITH TRANSGENIC PLANTS

Next Patent: METHOD FOR THE EX VIVO TREATMENT OF TUMOUR CELLS FROM PATIENTS WITH CML