VACCINE COMPRISING PERIPHERAL BLOOD MONONUCLEAR CELLS LOADED WITH NATURAL KILLER T CELL LIGAND AND ANTIGEN

Title:

VACCINE COMPRISING PERIPHERAL BLOOD MONONUCLEAR CELLS LOADED WITH NATURAL KILLER T CELL LIGAND AND ANTIGEN

Document Type and Number:

WIPO Patent Application WO/2024/058609

Kind Code:

A1

Abstract:

The present invention relates to an immunoprophylactic and therapeutic vaccine comprising peripheral blood mononuclear cells loaded with a natural killer T cell ligand and an antigen, and specifically, to an immunotherapeutic vaccine comprising peripheral blood mononuclear cells loaded with alpha-galactosylceramide, a natural killer T cell ligand and a type of glycolipid. A composition of the present invention is easy to obtain because there is no need to separate specific cells from peripheral blood mononuclear cells. In addition, immunization of peripheral blood mononuclear cells loaded with a natural killer T cell ligand and an antigen not only induces significant levels of activation of natural killer cells and natural killer T cells and cytotoxic T lymphocyte responses, but also has a synergistic effect in the treatment of malignant tumors and thus can be helpfully used as an anticancer immunotherapeutic agent.

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Inventors:

KANG CHANG-YUIL (KR)
SONG BOYEONG (KR)
JEON INSU (KR)

Application Number:

PCT/KR2023/013932

Publication Date:

March 21, 2024

Filing Date:

September 15, 2023

Export Citation:

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Assignee:

CELLID CO LTD (KR)

International Classes:

A61K39/00; A61K35/15; A61K35/17

Foreign References:

KR20090051598A	2009-05-22
KR100809873B1	2008-03-06
KR102122802B1	2020-06-16

Other References:

KUMAR SUDEEP; SUNAGAR RAJU; PHAM GIANG; GOSSELIN EDMUND J.; NALIN DAVID: "Ex vivoantigen-pulsed PBMCs generate potent and long lasting immunity to infection when administered as a vaccine", VACCINE, ELSEVIER, AMSTERDAM, NL, vol. 35, no. 7, 6 January 2017 (2017-01-06), AMSTERDAM, NL , pages 1080 - 1086, XP029904251, ISSN: 0264-410X, DOI: 10.1016/j.vaccine.2016.12.035
S. MOTOHASHI, K. NAGATO, N. KUNII, H. YAMAMOTO, K. YAMASAKI, K. OKITA, H. HANAOKA, N. SHIMIZU, M. SUZUKI, I. YOSHINO, M. TANIGUCHI: "A Phase I-II Study of ?-Galactosylceramide-Pulsed IL-2/GM-CSF-Cultured Peripheral Blood Mononuclear Cells in Patients with Advanced and Recurrent Non-Small Cell Lung Cancer", THE JOURNAL OF IMMUNOLOGY, WILLIAMS & WILKINS CO., US, vol. 182, no. 4, 15 February 2009 (2009-02-15), US , pages 2492 - 2501, XP055386155, ISSN: 0022-1767, DOI: 10.4049/jimmunol.0800126

Attorney, Agent or Firm:

LEE, Won Hee (KR)

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