Title:
VALVE MATERIAL HAVING SYNERGISTIC ANTI-COAGULATION AND ANTI-CALCIFICATION FUNCTIONS AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2021/254346
Kind Code:
A1
Abstract:
The present invention provides a valve material having synergistic anti-coagulation and anti-calcification functions and a preparation method therefor. The preparation method comprises the following steps: performing glutaraldehyde cross-linking treatment on an animal-derived biological valve material; immersing the treated valve material in a blocking solution containing an amine compound for 0.5-6 h, thereby blocking the remaining aldehyde groups after glutaraldehyde cross-linking; then placing the valve material into a reaction solution containing an anticoagulant and a cross-linking agent, and performing cross-linking treatment for 6-24 h at 4 °C-37 °C; and finally washing and obtaining the valve material, and storing the valve material in a mixed solvent of glutaraldehyde or isopropyl alcohol/glycerol. The method can effectively solve the problem of calcification and thrombosis caused by residual aldehyde groups in a valve material prepared by the existing method. The valve material prepared by the present method can be used as a valve material required for aortic valve, pulmonary valve, venous valve, mitral valve and tricuspid valve replacement.
Inventors:
WANG YUNBING (CN)
YANG LI (CN)
LUO RIFANG (CN)
LI LINHUA (CN)
YANG LI (CN)
LUO RIFANG (CN)
LI LINHUA (CN)
Application Number:
PCT/CN2021/100181
Publication Date:
December 23, 2021
Filing Date:
June 15, 2021
Export Citation:
Assignee:
JILIN VENUS HAOYUE MEDICAL LTD (CN)
International Classes:
A61L27/36; A61L27/54; A61L33/00; A61L33/10; A61L33/12
Foreign References:
| CN111658824A | 2020-09-15 | |||
| US5645587A | 1997-07-08 | |||
| CN109260517A | 2019-01-25 | |||
| CN101678152A | 2010-03-24 |
Attorney, Agent or Firm:
SHINY INTELLECTUAL PROPERTY FIRM (CN)
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