Title:
VALVE MATERIAL HAVING LONG-ACTING ANTITHROMBOSIS PROPERTY AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2021/254347
Kind Code:
A1
Abstract:
The present invention provides a valve material having a long-acting antithrombosis property and a preparation method therefor. The preparation method therefor comprises the following steps: performing glutaraldehyde cross-linking treatment on an animal-derived biological valve material, so that the valve material can resist decomposition for a long time; soaking the treated valve material in a formulation solution containing a cross-linking agent and a modifier for 10-60 min, then increasing the temperature to 30-60°C, and performing heat treatment for 1-12 h; and rinsing the valve material after heat treatment, so as to obtain the valve material. The valve material prepared by the method has excellent antithrombosis and anti-calcification properties, and can effectively solve the problem of calcification and thrombosis in the valve material treated by existing means of glutaraldehyde cross-linking. The valve material prepared by the present method can be used as a valve material required for aortic valve, pulmonary valve, venous valve, mitral valve and tricuspid valve replacement.
Inventors:
WANG YUNBING (CN)
LUO RIFANG (CN)
YANG LI (CN)
ZHANG FANJUN (CN)
LUO RIFANG (CN)
YANG LI (CN)
ZHANG FANJUN (CN)
Application Number:
PCT/CN2021/100182
Publication Date:
December 23, 2021
Filing Date:
June 15, 2021
Export Citation:
Assignee:
VENUS MEDTECH HANGZHOU INC (CN)
International Classes:
A61L27/36; A61L27/54; A61L27/56; A61L33/00; A61L33/04
Foreign References:
| CN111658825A | 2020-09-15 | |||
| CN109172867A | 2019-01-11 | |||
| CN101947147A | 2011-01-19 | |||
| CN101161293A | 2008-04-16 | |||
| CN107007887A | 2017-08-04 | |||
| CN106913909A | 2017-07-04 | |||
| CN108785747A | 2018-11-13 | |||
| US6471723B1 | 2002-10-29 |
Attorney, Agent or Firm:
SHINY INTELLECTUAL PROPERTY FIRM (CN)
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