VARIANT MICROORGANISM HAVING ABILITY TO PRODUCE 1,3-PROPANEDIOL, AND METHOD FOR PREPARING 1,3-PDO BY USING SAME

Title:

VARIANT MICROORGANISM HAVING ABILITY TO PRODUCE 1,3-PROPANEDIOL, AND METHOD FOR PREPARING 1,3-PDO BY USING SAME

Document Type and Number:

WIPO Patent Application WO/2019/143089

Kind Code:

A1

Abstract:

The present invention relates to: a variant microorganism in which a glycerol catabolism pathway and a 1,3-PDO biosynthetic metabolic pathway are introduced into a microorganism incapable of utilizing glycerol as a single carbon source; and a method for preparing 1,3-PDO by using same. According to the present invention, glycerol, which is a low cost material, is used as a single carbon source such that a variant microorganism having the ability to produce 1,3-PDO can be grown and, simultaneously, 1,3-PDO can be produced, and thus the present invention is useful for producing 1,3-PDO economically.

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Inventors:

LEE SANG YUP (KR)
CHO JAE SUNG (KR)
KIM JE WOONG (KR)
KO YOO SUNG (KR)
PRABOWO CINDY PRICILIA SURYA (KR)
HAN TAEHEE (KR)
KIM EUIDUK (KR)
CHOI JAE WON (KR)
CHO CHANGHEE (KR)
LEE JUN KYU (KR)

Application Number:

PCT/KR2019/000571

Publication Date:

July 25, 2019

Filing Date:

January 15, 2019

Export Citation:

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Assignee:

KOREA ADVANCED INST SCI & TECH (KR)
HANHWA CHEMICAL CORP (KR)

International Classes:

C12N15/77; C07K14/245; C12N9/04; C12N9/12; C12N9/88; C12P7/18

Foreign References:

KR101146080B1	2012-05-15
KR100830826B1	2008-05-19
KR20140145397A	2014-12-23
US8236994B2	2012-08-07
KR20130022691A	2013-03-07

Other References:

RITTMANN, D. ET AL.: "Engineering of a glycerol utilization pathway for amino acid production by cotynebacterium glutamicum.", APPL. ENVIRON MICROBIOL, vol. 74, no. 20, 2008, pages 6216 - 6222, XP002578554
HUANG, J. ET AL.: "Cofactor recycling for co-production of 1,3-propanediol and glutamate by metabolically engineered Corynebacterium glutamicum", SCI. REP., vol. 7, no. 42246, 2017, pages 1 - 10, XP055627585
LEE ET AL., RENEWABLE AND SUSTAINABLE ENERGY REVIEWS, vol. 42, pages 963 - 972
HUANG ET AL., SCIENTIFIC REPORTS, vol. 7, 2017, pages 42246
NEUMANN ET AL., EMBO J., vol. 1, 1982, pages 841
YIM S.S. ET AL., BIOTECHNOL. BIOENG., vol. 110, 2013, pages 2959
EIKMANNS ET AL., GENE, vol. 102, 1991, pages 93
See also references of EP 3741860A4

Attorney, Agent or Firm:

LEE, Cheo Young et al. (KR)

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