Title:
VAULT AND VAULT-LIKE CARRIER MOLECULES
Document Type and Number:
WIPO Patent Application WO2004081533
Kind Code:
A3
Abstract:
A method of using vaults as carrier molecules to deliver one or more than one substance to an organism, or to a specific tissue or to specific cells, or to an environmental medium. A vault-like particle. A method of preventing damage by one or more than one substance to an organism, to a specific tissue, to specific cells, or to an environmental medium, by sequestering the one or more than one substance within a vault-like particle. A method of delivering one or more than one substance or a sensor to an organism, to a specific tissue, to specific cells, or to an environmental medium. According to another embodiment of the present invention, there is provided a method of making vault-like particles, and making vault-like particles comprising one or more than one substance, or one or more than one sensor.
Inventors:
ROME LEONARD H (US)
KICKHOEFER VALERIE A (US)
RAVAL-FERNANDES SUJNA (US)
STEWART PHOEBE L (US)
KICKHOEFER VALERIE A (US)
RAVAL-FERNANDES SUJNA (US)
STEWART PHOEBE L (US)
Application Number:
PCT/US2004/007434
Publication Date:
May 06, 2005
Filing Date:
March 10, 2004
Export Citation:
Assignee:
UNIV CALIFORNIA (US)
ROME LEONARD H (US)
KICKHOEFER VALERIE A (US)
RAVAL-FERNANDES SUJNA (US)
STEWART PHOEBE L (US)
ROME LEONARD H (US)
KICKHOEFER VALERIE A (US)
RAVAL-FERNANDES SUJNA (US)
STEWART PHOEBE L (US)
International Classes:
A61K38/16; A61K38/17; A61K47/48; C07K14/435; C07K14/47; C12N5/10; C12N15/63; C12N15/64; C12N15/866; C12Q1/68; C12Q1/70; A61K38/00; G01N; (IPC1-7): A61K38/16; A61K38/17; C12N15/866; C12N15/63; C12N15/64; C12N5/10; C07K14/435; C12Q1/68; C12Q1/70
Foreign References:
| US6555347B1 | 2003-04-29 | |||
| US6599728B2 | 2003-07-29 |
Other References:
SUPRENANT K.A.: "Valut ribonucleoprotein particles: sarcophagi, gondolas, or safety deposit boxes", BIOCHEMISTRY, vol. 41, no. 49, 10 December 2002 (2002-12-10), pages 14447 - 14454, XP002985240
VAN ZON ET AL.: "Structural domains of vault proteins: a role for the coiled domain in vault assembly", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 291, no. 3, 2002, pages 535 - 541, XP002985241
VAN ZON ET AL.: "Structural domains of vault proteins: a role for the coiled domain in vault assembly", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 291, no. 3, 2002, pages 535 - 541, XP002985241
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