Title:
VIRULENCE ATTENUATED BACTERIA BASED PROTEIN DELIVERY
Document Type and Number:
WIPO Patent Application WO/2018/115140
Kind Code:
A3
Abstract:
The present invention relates to recombinant virulence attenuated Gram-negative bacterial strains and its use in a method of treating cancer in a subject.
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Inventors:
ITTIG SIMON (CH)
AMSTUTZ MARLISE (CH)
KASPER CHRISTOPH (CH)
AMSTUTZ MARLISE (CH)
KASPER CHRISTOPH (CH)
Application Number:
PCT/EP2017/083853
Publication Date:
August 09, 2018
Filing Date:
December 20, 2017
Export Citation:
Assignee:
UNIV BASEL (CH)
International Classes:
C07K14/195; C07K14/52; C12N15/70; C12N15/74
Domestic Patent References:
| WO1999045098A2 | 1999-09-10 | |||
| WO2007044406A2 | 2007-04-19 | |||
| WO2015177197A1 | 2015-11-26 | |||
| WO2002026819A2 | 2002-04-04 |
Other References:
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H. RUSSMANN ET AL: "Protection Against Murine Listeriosis by Oral Vaccination with Recombinant Salmonella Expressing Hybrid Yersinia Type III Proteins", THE JOURNAL OF IMMUNOLOGY, vol. 167, no. 1, 1 July 2001 (2001-07-01), US, pages 357 - 365, XP055362697, ISSN: 0022-1767, DOI: 10.4049/jimmunol.167.1.357
XIAN-YANG LI ET AL: "Tumor suppressor activity of RIG-I", MOLECULAR & CELLULAR ONCOLOGY, vol. 1, no. 4, 8 December 2014 (2014-12-08), pages e968016, XP055366048, DOI: 10.4161/23723548.2014.968016
KATJA BÖHME ET AL: "Concerted Actions of a Thermo-labile Regulator and a Unique Intergenic RNA Thermosensor Control Yersinia Virulence", PLOS PATHOGENS, vol. 8, no. 2, 16 February 2012 (2012-02-16), pages e1002518, XP055365892, DOI: 10.1371/journal.ppat.1002518
JIAXI WU ET AL: "Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids", ANNUAL REVIEW OF IMMUNOLOGY., vol. 32, no. 1, 21 March 2014 (2014-03-21), US, pages 461 - 488, XP055366371, ISSN: 0732-0582, DOI: 10.1146/annurev-immunol-032713-120156
DE N ET AL: "Determinants for the Activation and Autoinhibition of the Diguanylate Cyclase Response Regulator WspR", JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS, UNITED KINGDOM, vol. 393, no. 3, 30 October 2009 (2009-10-30), pages 619 - 633, XP026676221, ISSN: 0022-2836, [retrieved on 20090818], DOI: 10.1016/J.JMB.2009.08.030
LETICIA CORRALES ET AL: "Direct activation of STING in the tumor microenvironment with synthetic cyclic dinucleotide derivatives leads to potent and systemic tumor-specific immunity", JOURNAL FOR IMMUNOTHERAPY OF CANCER, BIOMED CENTRAL LTD, LONDON, UK, vol. 2, no. Suppl 3, 6 November 2014 (2014-11-06), pages O10, XP021202342, ISSN: 2051-1426, DOI: 10.1186/2051-1426-2-S3-O10
H. RUSSMANN ET AL: "Protection Against Murine Listeriosis by Oral Vaccination with Recombinant Salmonella Expressing Hybrid Yersinia Type III Proteins", THE JOURNAL OF IMMUNOLOGY, vol. 167, no. 1, 1 July 2001 (2001-07-01), US, pages 357 - 365, XP055362697, ISSN: 0022-1767, DOI: 10.4049/jimmunol.167.1.357
XIAN-YANG LI ET AL: "Tumor suppressor activity of RIG-I", MOLECULAR & CELLULAR ONCOLOGY, vol. 1, no. 4, 8 December 2014 (2014-12-08), pages e968016, XP055366048, DOI: 10.4161/23723548.2014.968016
KATJA BÖHME ET AL: "Concerted Actions of a Thermo-labile Regulator and a Unique Intergenic RNA Thermosensor Control Yersinia Virulence", PLOS PATHOGENS, vol. 8, no. 2, 16 February 2012 (2012-02-16), pages e1002518, XP055365892, DOI: 10.1371/journal.ppat.1002518
JIAXI WU ET AL: "Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids", ANNUAL REVIEW OF IMMUNOLOGY., vol. 32, no. 1, 21 March 2014 (2014-03-21), US, pages 461 - 488, XP055366371, ISSN: 0732-0582, DOI: 10.1146/annurev-immunol-032713-120156
DE N ET AL: "Determinants for the Activation and Autoinhibition of the Diguanylate Cyclase Response Regulator WspR", JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS, UNITED KINGDOM, vol. 393, no. 3, 30 October 2009 (2009-10-30), pages 619 - 633, XP026676221, ISSN: 0022-2836, [retrieved on 20090818], DOI: 10.1016/J.JMB.2009.08.030
LETICIA CORRALES ET AL: "Direct activation of STING in the tumor microenvironment with synthetic cyclic dinucleotide derivatives leads to potent and systemic tumor-specific immunity", JOURNAL FOR IMMUNOTHERAPY OF CANCER, BIOMED CENTRAL LTD, LONDON, UK, vol. 2, no. Suppl 3, 6 November 2014 (2014-11-06), pages O10, XP021202342, ISSN: 2051-1426, DOI: 10.1186/2051-1426-2-S3-O10
Attorney, Agent or Firm:
LATSCHA SCHÖLLHORN PARTNER AG (CH)
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