Title:
VIRUS VECTOR-PRODUCING CELLS AND VECTOR PRODUCTION METHOD
Document Type and Number:
WIPO Patent Application WO/2014/092090
Kind Code:
A1
Abstract:
The present invention provides cells having the ability to produce virus vectors in which nucleic acids for coding toxins are included, the cells comprising an anti-toxin expression cassette and being characterised in that the expression cassette comprises an expression control region having a sequence corresponding to a transcriptional activator binding region, and a nucleic acid that codes anti-toxins that can be readily connected to the expression control region. Also provided are: a production method which uses the cells and which is for producing virus vectors in which nucleic acids for coding toxins are included; a production method for the cells; and cells that are used in the present invention and that comprise the anti-toxin expression cassette on a chromosome.
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Inventors:
DODO KATSUYUKI (JP)
KAWANO YASUHIRO (JP)
CHONO HIDETO (JP)
MINENO JUNICHI (JP)
KAWANO YASUHIRO (JP)
CHONO HIDETO (JP)
MINENO JUNICHI (JP)
Application Number:
PCT/JP2013/083111
Publication Date:
June 19, 2014
Filing Date:
December 10, 2013
Export Citation:
Assignee:
TAKARA BIO INC (JP)
International Classes:
C12N5/10; C12N15/09
Domestic Patent References:
| WO2007020873A1 | 2007-02-22 | |||
| WO2008133137A1 | 2008-11-06 |
Other References:
HAN, PAULA ET AL.: "Transactivation of heterologous promoters by HIV-1 tat", NUCLEIC ACIDS RES., vol. 19, no. 25, 1991, pages 7225 - 7229
CHO, MYUNG-SAM ET AL.: "An oriP expression vector containing the HIV-1 Tat/TAR transactivation axis produces high levels of protein expression in mammalian cells", CYTOTECHNOLOGY, vol. 37, 2001, pages 23 - 30
CHO, MYUNG-SAM ET AL.: "An oriP expression vector containing the HIV-1 Tat/TAR transactivation axis produces high levels of protein expression in mammalian cells", CYTOTECHNOLOGY, vol. 37, 2001, pages 23 - 30
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (JP)
Mutsumi Sameshima (JP)
Mutsumi Sameshima (JP)
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