Title:
WATER SOLUBLE MULTI-BIOTIN-CONTAINING COMPOUNDS
Document Type and Number:
WIPO Patent Application WO2000072802
Kind Code:
A3
Abstract:
Water soluble discrete multi-biotin-containing compounds with at least three (3) biotin moieties are disclosed. The water soluble biotin-containing compounds may additionally comprise one or more moieties that confer resistance to cleavage by biotinidase or that is cleavable in vitro or in vivo. The discrete multi-biotin-containing compounds may include a reactive moiety that provides a site for reaction with yet another moiety, such as a targeting, diagnostic or therapeutic functional moiety. Biotinylation reagents comprising water soluble linker moieties are also disclosed and may additionally comprise a biotinidase protective group. Methods for amplifying the number of sites for binding biotin-binding proteins at a selected target using multi-biotin compounds are also disclosed.
Inventors:
WILBUR SCOTT D
PATHARE PRADIP M
HAMLIN DONALD K
WEERAWARNA ANANDA S
PATHARE PRADIP M
HAMLIN DONALD K
WEERAWARNA ANANDA S
Application Number:
PCT/US2000/015081
Publication Date:
February 07, 2002
Filing Date:
June 01, 2000
Export Citation:
Assignee:
UNIV WASHINGTON (US)
International Classes:
C07D495/04; C07D519/00; (IPC1-7): A61K51/00; C12P13/18
Foreign References:
| US5714166A | 1998-02-03 | |||
| US5482698A | 1996-01-09 | |||
| US5521319A | 1996-05-28 | |||
| US5750357A | 1998-05-12 |
Other References:
See also references of EP 1196199A4
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