Title:
alpha -AMINO- beta -SULFONYL HYDROXAMIC ACID COMPOUNDS
Document Type and Number:
WIPO Patent Application WO2000071514
Kind Code:
A8
Abstract:
A family of molecules of formula (A) in which R<1> is a 5- or 6-membered carbocyclo, heterocyclo, aryl or heteroaryl radical such that its size defined by certain parameters; R<20> is -O-R<21>, -NR<13>-O-R<22> or -NR<13>-O-R<14>; and the other variables are as defined in the claims, is disclosed that inhibit matrix metalloproteinase (MMP) activity, and particularly inhibit the activity of one or more of MMP-2, MMP-9, or MMP-13, while generally exhibiting little activity against MMP-1. A contemplated compound also exhibits little inhibition of the production of TNF. Also disclosed are process for preparing a contemplated compound and for treating a mammal having a condition associated with pathological matrix metalloproteinase activity.
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Inventors:
BARTA THOMAS E (US)
BECKER DANIEL P (US)
BEDELL LOUIS J (US)
DE CRESCENZO GARY A (US)
FRESKOS JOHN N (US)
GETMAN DANIEL P (US)
HEINTZ ROBERT M (US)
HOCKERMAN SUSAN L (US)
LI HUI (US)
MISCHKE BRENT V (US)
VILLAMIL CLARA I (US)
BECKER DANIEL P (US)
BEDELL LOUIS J (US)
DE CRESCENZO GARY A (US)
FRESKOS JOHN N (US)
GETMAN DANIEL P (US)
HEINTZ ROBERT M (US)
HOCKERMAN SUSAN L (US)
LI HUI (US)
MISCHKE BRENT V (US)
VILLAMIL CLARA I (US)
Application Number:
PCT/US2000/009807
Publication Date:
February 22, 2001
Filing Date:
May 17, 2000
Export Citation:
Assignee:
SEARLE & CO (US)
BARTA THOMAS E (US)
BECKER DANIEL P (US)
BEDELL LOUIS J (US)
CRESCENZO GARY A DE (US)
FRESKOS JOHN N (US)
GETMAN DANIEL P (US)
HEINTZ ROBERT M (US)
HOCKERMAN SUSAN L (US)
LI HUI (US)
MISCHKE BRENT V (US)
VILLAMIL CLARA I (US)
BARTA THOMAS E (US)
BECKER DANIEL P (US)
BEDELL LOUIS J (US)
CRESCENZO GARY A DE (US)
FRESKOS JOHN N (US)
GETMAN DANIEL P (US)
HEINTZ ROBERT M (US)
HOCKERMAN SUSAN L (US)
LI HUI (US)
MISCHKE BRENT V (US)
VILLAMIL CLARA I (US)
International Classes:
A61K31/16; A61K31/164; A61K31/166; A61K31/17; A61K31/18; A61K31/197; A61K31/222; A61K31/27; A61K31/341; A61K31/351; A61K31/4409; A61K31/4453; A61K31/47; A61P1/02; C07D215/50; A61P1/04; A61P7/00; A61P7/02; A61P11/00; A61P13/12; A61P17/02; A61P19/00; A61P19/02; A61P25/28; A61P27/02; A61P29/00; A61P35/04; A61P43/00; C07C317/48; C07C317/50; C07C323/65; C07D207/09; C07D211/14; C07D213/38; C07D307/58; C07D307/68; C07D309/10; C07K5/06; A61K38/00; (IPC1-7): C07C317/48; C07C317/50; C07C323/65; C07D211/62; C07D213/56; C07D213/81; C07D213/82; C07D215/50; C07D295/15; C07D307/68; C07D317/58; C07K5/062; A61K31/10; A61P7/00; A61P11/00
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