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WO/1995/028384A1 |
The invention provides for diazo-phenanthrenone compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to inhibit steroid 5-'alpha' reductase. The invention also provides processes for pr...
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WO/1995/026328A1 |
Compounds of formula (I), processes for their preparation and their use as CNS agents are disclosed, in which R1 is hydrogen, halogen, C1-6alkyl, C3-6cycloalkyl, COC1-6alkyl, C1-6alkoxy, hydroxy, hydroxyC1-6alkyl, hydroxyC1-6alkoxy, C1-6...
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WO/1995/024898A1 |
Novel complexes of nitric oxide (NO) and amines are described where the amine is a known cardiovascular agent having at least one or more primary or secondary amino groups and whereby the resulting complex is capable under physiological ...
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WO/1995/023130A1 |
The present invention is a method of preparing a 4,6-bisarylazoresorcinol comprising reacting an aryldiazonium salt and resorcinol in the presence of a base and a reaction medium containing water and a water-miscible solvent at a tempera...
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WO/1995/020578A1 |
This invention is directed to compounds of formula (I), wherein R1 is an optionally substituted lower alkyl group; R2 is an optionally substituted oxaaliphatic group; R3 is an optionally substituted aryl group or an optionally substitute...
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WO/1995/019974A2 |
Calixarene-based compounds are described which have biological activity, particularly anti-bacterial, anti-fungal, anti-cancer and anti-viral activity. Some compounds have been found to have anti-HIV activity. The compounds are calixaren...
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WO/1995/018832A1 |
This invention describes a series of novel polyamino-carboxylate chelators suitable for attaching metal ions to polypeptide molecules. Polypeptide-polyaminocarboxylate conjugates prepared using the novel chelators form stable complexes w...
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WO/1995/018186A1 |
The design and synthesis of novel aminimide-derived molecular modules and the use of the modules in the construction of new molecules and fabricated materials is disclosed. The new molecules and fabricated materials are molecular recogni...
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WO/1995/016666A1 |
A process for producing a diazomethane derivative by oxidizing a hydrazone derivative in a two-phase system containing: a) an aqueous solution of a mixture of a caustic alkali and an alkali metal hypochlorite in respective concentrations...
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WO/1995/012572A1 |
The present invention provides a compound of formula (I) processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and a method of treating disor...
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WO/1995/012569A1 |
A process for preparing substituted aromatic amines is provided which comprises contacting a substituted aromatic azo compound and an alcohol selected from the group consisting of aliphatic alcohols, cycloaliphatic alcohols, arylalkyl al...
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WO/1995/011278A1 |
Diphenylamines have formula (I), in which the ring A may be benzoanellated; D stands for an aryl radical or for a five-membered aromatic heterocyclic residue that has 1 to 3 heteroatoms in the heterocyclic ring selected from the group th...
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WO/1995/000473A1 |
A novel calix[4]arene compound, application of the compounds as an active component in a calcium sensitive sensor, and a calcium sensitive sensor containing the compound. The calix[4]arene compound has general formula (I). The sensor is ...
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WO/1994/025425A1 |
A process for preparing substituted aromatic amines is provided which comprises contacting a nucleophilic compound and an azo containing compound in the presence of a suitable solvent system, reacting the nucleophilic compound and the az...
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WO/1994/008051A1 |
Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produc...
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WO/1994/004483A1 |
New chromoionophores of formula (IV) wherein a = 0-3, b = 0 or 1, c = 0 or 1, x = 0 or 1, y = 0 or 1, z = 0 or 1; R\', which may be the same or different in each aryl group, is H, halogen, hydrocarbyl, aryl, hydrocarbylaryl or a substitu...
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WO/1994/002465A1 |
This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation an...
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WO/1993/024517A2 |
The subjects of the invention are kits comprising free or support bound peptide mixtures (sub-libraries) as components, methods for their preparation and method for their use in discovery of bioactive peptides as potential drugs. Groups ...
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WO/1993/024634A1 |
Therapeutic agents and methods for the treatment of immunologically mediated diseases and malignancies of myeloid cell or lymphoid cell origin. These particular methods utilize the characterization of particular activation mechanisms imp...
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WO/1993/024450A1 |
A process for preparing substituted aromatic azo compounds is provided which comprises contacting a nucleophilic compound and an azo containing compound in the presence of a suitable solvent system, and reacting the nucleophilic compound...
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WO/1993/014777A1 |
Novel peptidyl derivatives of formula (I) are found to be potent inhibitors of interleukin-1beta converting enzyme (ICE). Compounds of formula (I) may be useful in the treatment of inflammatory or immune-based diseases of the lung and ai...
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WO/1993/013768A1 |
The present invention relates to the therapeutic uses of thiol-oxidizing agents and of sulfhydryl-alkylating agents. The sulfhydryl-alkylating agents are maleimide and its derivatives. Therapeutic compositions comprising such agents are ...
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WO/1993/010083A1 |
Compounds having structural formulae (I) and (II) where X, Y, R and Z are defined in the specification are disclosed. The compounds of this invention are effective for controlling mites, nematodes, rice planthopper, tobacco budworm, and ...
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WO/1993/009089A1 |
The present invention is directed to bistriazene compounds, pharmaceutical compositions containing effective anti-cancer amounts of these compounds, a method for treating cancer comprising administering to affected subjects an anti-cance...
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WO/1993/007114A1 |
There are disclosed cardiovascularly active compounds possessing antihypertensive properties, and pharmaceutical compositions containing these agents and a method of treating cardiovascular disorders with the compounds. The active compon...
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WO/1992/014696A2 |
This invention relates to substituted alpha-aminoaldehydes, pharmaceutical compositions containing them and methods for using such compounds as antiviral agents.
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WO/1992/006074A1 |
A photosensitive azo compound represented by general formula (I), wherein R?1¿ and R?2¿ may be the same or different from each other and each represents halogen, halogenated C¿1? to C¿6? alkyl, -NO¿2?, -SC=N, -C=N, -SO¿3?H, -C¿n?F...
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WO/1991/017753A1 |
The present invention is directed to bistriazene compounds, pharmaceutical compositions containing effective anti-cancer amounts of these compounds, a method for treating cancer comprising administering to affected subjects an anti-cance...
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WO/1991/016287A1 |
1,2,4-Triflurobenzene and 1-chloro-3,4-difluorobenzene are prepared by reacting 2,4-difluoroaniline and 5-chloro-2-fluoroaniline, respectively, with t-butyl nitrite in the presence of borontrifluoride etherate complex, followed by the th...
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WO/1991/013847A1 |
1-Chloro-3,4-difluorobenzene, an intermediate in the production of certain quinolone drugs, is produced by converting a chlorofluoro-aniline into the corresponding diazonium fluoborate, and pyrolysing the latter to give the 1-chloro-3,4-...
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WO/1991/010634A1 |
Nitrogen-containing aromatic heterocyclic ligand-metal complexes and their use for the activation of hydrogen peroxide and dioxygen are disclosed. Processes whereby activated hydrogen peroxide or dioxygen are used to transform various or...
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WO/1991/009842A1 |
Azo-type optically active compounds and polymers are provided based on compounds of the general structure [substituted aryl]-N=N-[substituted aryl] wherein aryl substituents are introduced which hinder or prohibit rotation around the sin...
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WO/1991/009087A1 |
Bistriazene compounds such as (I) are useful for crosslinking polymers such as poly(imides), poly(aryl ether ketones), poly(aryl ether sulfones), poly(quinolines), poly(quinoxalines), and nonaromatic fluoropolymers having aliphatic C-H g...
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WO/1990/014881A2 |
A new series of bifunctional chelating agents useful for attaching metal ions to proteins, polypeptides and other polymers and methods for their preparation are described. These reagents are unique in their ability to bind a variety of m...
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WO/1990/012073A1 |
The invention concerns trifluoromethylcyclohexane derivatives of the formula (I) in which R, A?1¿, A?2¿, (a), Z?1¿, Z?2¿ and o are as defined in claim 1. These compounds can be used as components of liquid-crystal media for electro-o...
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WO/1990/011523A2 |
The present invention concerns a method to catalyze reporter deposition to improve detection or quantitation of an analyte in a sample by amplifying the detector signal which comprises immobilizing an analyte dependent enzyme activation ...
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WO/1989/009207A1 |
A substituted 1-(2-chlorethyl)-3-acyl-3-alkyltriazene of formula (I), in which R1 is 1-oxoalkyl containing from two to eight carbon atoms, fluorinated 1-oxoalkyls containing from two to eight carbon atoms and substituted with up to three...
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WO/1989/007098A1 |
The present invention concerns a compound having structure (I), wherein R1 is a branched- or unbranched-chain alkylamine having from 2 to 20 atoms in the chain and wherein each of R2, R3 and R4 is the same or different and is hydrogen or...
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WO/1989/004822A1 |
Disclosed is a process for continuous preparation of aromatic diazonium fluoride salts wherein diazotizable aromatic primary amines are continuously diazotized in a reactor containing a plurality of sequential reaction zones, wherein a p...
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WO1987003278A2 |
A ring contraction approach is applied to preparation of cyclopentane derivatives, especially 2,2,5,5-tetra-methylcyclopentanecarboxylic acid from cyclohexane compounds. In one aspect, a cyclohexane diazoketone is reacted with an amine (...
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WO/1986/003195A1 |
A compound having an inhibitory effect on 15-hydroxy-prostaglandin dehydrogenase (PGDH). The compound has structure (I), in which X, Y and Z are hydrogen, carboxy or lower alkoxy-carbonyl, one of X, Y and Z always being hydrogen and the ...
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JP2023184545A |
To provide a composition capable of suppressing a decrease in a dichroic ratio of a polarizing plate.Provided is a composition containing a compound of formula (1), and a polymerizable liquid crystal compound or a liquid crystalline poly...
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JP2023546100A |
Glutamine analogs, compositions containing glutamine analogs and uses thereof.
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JP2023538785A |
Automatic equipment for the production, utilization and quenching of highly toxic diazomethane (Diazo-M-pen and Diazo-M-cube) consisting of an integrated pump, tubular flow reactor, liquid-liquid microseparator, solid MOF quencher, etc. ).
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JP7329921B2 |
To provide: a coloring composition and a color filter coloring agent that contain an azo compound with good coloring (color gamut, luminance, contrast etc.) and excellent solubility; and a color filter using the color filter coloring age...
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JP2023113166A |
To provide a water soluble azobenzene compound isomerized by irradiation with visible green light.A water soluble azobenzene compound is represented by the following formula. M is Na or K, X is fluorine, chlorine, or bromine, and Y is an...
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JP7298105B2 |
A full continuous flow synthesis process of fluorine-containing aromatic hydrocarbon compounds. Aromatic amine and hydrogen fluoride are respectively pumped into thermostats A and B, then flow into micro-channel reactor C for salt formin...
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JP7247511B2 |
Provided are a liquid crystal alignment film capable of being given anisotropy through photoalignment and stable to light, and a liquid crystal display device capable of keeping a high voltage holding ratio without degradation of display...
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JP7234673B2 |
To provide a liquid crystal alignment film which allows for imparting anisotropy by a photo-alignment method and has a high transmittance, and to provide a liquid crystal display element.A liquid crystal photo-aligning agent is used, con...
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JP7217004B2 |
To provide a method for producing a novel metallic luster organic crystalline thin film.A method for producing a metallic luster organic crystal thin film includes: a step of applying electric field to a dispersion in which crystal parti...
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