Acyclic or Carbocyclic Compounds

Matches 201 - 250 out of 957	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >

Document	Document Title
WO/1997/034865A1	TRICYCLIC COMPOUNDS HAVING ACTIVITY SPECIFIC FOR INTEGRINS, PARTICULARLY 'alpha'v'beta'3 INTEGRINS, METHOD FOR PREPARING SAME, INTERMEDIATES THEREFOR, USE OF SAID COMPOUNDS AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME Compounds of formula (I), wherein R1, R2, R3, R4, R5 and G are as defined in the description and the dotted lines indicate an optional second bond, as well as the acid, base and ester addition salts thereof, a method for preparing said c...
WO/1997/033862A1	PESTICIDAL HYDRAZIDE DERIVATIVES A compound of formula (I) wherein R is a) phenyl; phenyl (C1-C4 alkoxy); phenoxy; or benzyl; the phenyl ring of each substituent being optionally substituted with one or more of halogen, nitro, C1-C8 alkyl, C1-C8 alkoxy, C1-C8 haloalkyl,...
WO/1997/025309A1	CARBAMOYLOXY DERIVATIVES OF MUTILINE AND THEIR USE AS ANTIBACTERIALS Derivatives of mutiline of formula (1A) and pharmaceutically acceptable salts and derivatives thereof, in which R1 is ethyl or vinyl, Y is a carbamoyloxy group, in which the N-atom is unsubstituted, or mono- or di-substituted, are useful...
WO/1997/023243A1	BRANCHED HYDRAZONE LINKERS Branched hydrazone linkers for linking a targeting ligand such as an antibody to a therapeutically active drug. The point of branching is at a polyvalent atom and the number of drugs increases by a factor of two for each generation of br...
WO/1997/023447A1	N-ACYLAMINOALKYLHYDRAZINECARBOXIMIDAMIDES The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging) using compounds of formula (I), wherein alk is a straight or branched chain alkylene group containing from 2 to 8 carbon ...
WO/1997/019935A1	PROCESSES AND COMPOUNDS FOR PREPARING CYCLIC UREA FUNGICIDES Processes are disclosed for preparing compounds of Formula (I), for preparing a compound of Formula (II), for preparing a compound of Formula (III) and for preparing a compound of Formula (IV), wherein R3 and R4 are each independently H,...
WO/1997/016433A1	PROTEASE INHIBITORS The present invention provides compounds which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, includin...
WO/1997/012862A1	CBI ANALOGS OF CC-1065 AND THE DUOCARMYCINS Analogs of the antitumor antibiotics CC-1065 and the duocarmycins incorporate the 1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) alkylation subunit. The CBI-based analogs have potent cytotoxic activity and are useful as efficac...
WO/1997/009303A1	ALPHA-HYDRAZINO ACID DERIVATIVES AND METHOD FOR MAKING SAME An 'alpha'-hydrazino acid derivative of general formula (I) is described, wherein R1, R2, R3 are hydrogen or a carbon radical, such that when R2 and R3 are different, C* is an asymmetric carbon of L, D or DL configuration, and R4 and R5 ...
WO/1997/007091A1	FLUOROBUTENIC ACID HYDRAZIDES The invention concerns novel fluorobutenic acid hydrazides of formula (I) in which: Y stands for C=O, C=S or SO2; R1 stands for hydrogen or halogen; and R2 stands for alkyl, alkyl halide, alkoxyalkyl, alkylthioalkyl, cycloalkyl, alkenyl,...
WO/1997/003678A1	CYCLO-OXYGENASE INHIBITOR AND AMIDINE DERIVATIVE SALTS, PREPARATION METHOD THEREFOR, USE THEREOF AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID SALTS Cyclo-oxygenase inhibitor and amidine derivative salts, preparation methods therefor, pharmaceutical compositions containing said salts and the use thereof particularly as NO synthase and cyclo-oxygenase inhibitors, are disclosed.
WO/1997/002257A1	HYDRAZINE DERIVATIVES Compounds having structural formula (I) or (II), wherein R is C1-C6 alkoxy or C1-C6 alkyl; R1 is fluorenyl, thienyl, pyridyl or thiazolyl, unsubstituted or substituted by one or more substituents selected from C1-C4 alkoxy, C1-C4 alkyl, ...
WO/1997/002255A1	TRIAZOLINE AND ISOXAZOLINE BIS-OXIME DERIVATIVES AND THEIR USE AS PESTICIDES Bis-oxime derivatives of formula (I) in which A is (a) or (b), where W is oxygen or sulfur, and the other substituents defined as follows: R1 = hydrogen, C1-C4alkyl; cyclopropyl; R2 = hydrogen, C1-C6alkyl; halo(C1-C6) alkyl; C2-C6alkoxya...
WO/1997/001543A1	1-AMINO-3-BENZYLURACILS The invention concerns 1-amino-3-benzyluracils of formula (I) and their salts. In said formula (I), R1 = halogen; R2, R3 = H, CN, SCN, halogen, C1-C4-alkyl halide, C1-C4-alkoxy halide, C1-C4-alkylthio halide; R4 = R3 + C1-C4-alkyl, C1-C4...
WO/1997/000853A1	BICYCLIC AMINO DERIVATIVES AND PGD2 ANTAGONIST CONTAINING THE SAME Compounds of general formula (I), salts thereof or hydrates thereof wherein (a) represents (b) or (c), for example, the compounds (d) and (e), which are useful as a PGD2 antagonist and thus usable in, for example, a remedy for systemic m...
WO/1996/040628A1	SEMICARBAZONES HAVING CNS ACTIVITY AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME A compound of general formula (I) useful as an anticonvulsant for disorders of the central nervous system wherein: R1, R2, R3 and R4 may be the same or different and each represents a hydrogen or halogen atom, or a C1-9alkyl, C3-9cycloal...
WO/1996/040663A1	DI- AND TRI-AMINOGUANIDINES AND THEIR USE TO INHIBIT THE ADVANCED GLYCOSYLATION OF PROTEINS The present invention relates to compounds, compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises a di- or tri-aminoguanidine of formula (I), capable o...
WO/1996/040743A2	INHIBITORS OF FACTOR Xa Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
WO/1996/040622A1	BIS-(2-ARYL)HYDRAZONES AS INHIBITORS OF THE FORMATION OF ADVANCED GLYCOSYLATION ENDPRODUCTS The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises a bis-(2-aryl)hydrazone capable of inhibiting the formation of a...
WO/1996/031467A1	AN ARTHROPODICIDAL OXADIAZINE INTERMEDIATE Provided is a compound of formula (I). This compound is an intermediate to and is used for preparing the arthropodicidal oxidiazine Compound (II) described in the specification.
WO/1996/030329A1	SUBSTITUTED BENZENE DERIVATIVES USEFUL AS NEURAMINIDASE INHIBITORS The invention relates to substituted benzenes and derivatives thereof, useful as neuraminidase inhibitors, to pharmaceutical compositions comprising such compounds, and to methods of using these compounds for treating viral and other inf...
WO/1996/021450A2	BIS-[HYDRAZONES] The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises a dioone bis[hydrazone] capable of inhibiting the formation of a...
WO/1996/020934A1	PROCESS FOR THE PREPARATION OF LAMOTRIGINE The invention provides a process for producing lamotrigine of formula (I) which process comprises subjecting a compound of formula (II), wherein R is CN or CONH2, in an organic solvent, to ultraviolet or visible radiation and, when R is ...
WO/1996/018644A1	AROMATIC HETEROCYCLIC DERIVATIVES AS ENZYME INHIBITORS The present invention discloses peptide aldehydes of formula (I) which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them a...
WO/1996/016031A1	AMINOGUANIDINE CARBOXYLATES FOR THE TREATMENT OF NON-INSULIN-DEPENDENT DIABETES MELLITUS The present invention provides novel compounds of the formulae (I): AG-(CH2)n-CO2R1 and (II) or pharmacologically acceptable salts thereof, wherein AG is: a) N-aminoguanidine, b) N,N'-diaminoguanidine, or c) N,N',N"-triaminoguanidine; an...
WO/1996/013509A1	FLUOROALKENYL COMPOUNDS AND THEIR USE AS PEST CONTROL AGENTS Fluorinated alkene compounds having structure (I) wherein Q is -(C=S)-R1, -(C=W)-R2, or -(P=W)R3R4; wherein W is O or S; and R1 to R4 are as defined in claim 1; are useful for controlling nematodes, insects, and acarids that prey on agri...
WO/1996/010560A1	BENZAMIDE SEMICARBAZONE DERIVATIVES AND THEIR USE AS PESTICIDES A semicarbazone derivative of formula (I), wherein W is an oxygen atom or a sulfur atom; each of X, Y and Z which are independent of one another, is a halogen atom, a hydroxyl group, a cyano group, a nitro group, SCN, a trimethylsilyl gr...
WO/1996/005180A1	RETROVIRAL PROTEASE INHIBITING 1,2,4-TRIAZACYCLOHEPTANES A retriviral protease inhibiting compound of formula (A) is disclosed.
WO/1996/003418A1	SOLUBLE COMBINATORIAL LIBRARIES The present invention relates to novel soluble combinatorial libraries, comprising a soluble phase in solution attached to a core molecule, and allowing the improved high-yield and efficient production of soluble combinatorial libraries....
WO/1996/001252A1	SEMICARBAZIDE DERIVATIVE AND COATING COMPOSITION CONTAINING THE DERIVATIVE A semicarbazide derivative represented by general formula (1) and a terminally blocked derivative thereof (wherein R1 represents a polyisocyanate residue free from a terminal isocyanate group or a triisocyanate residue free from a termin...
WO/1995/029889A1	PERHALOALKOXYBENZENOPHENONE HYDRAZONES AND THEIR USE AS PESTICIDES Compounds of formula (I) in which X is (a) or (b), n is 0, 1, 2, 3, 4 or 5, where if n is greater than 1, the radicals R2 are identical or different; o is 0, 1, 2, 3 or 4, where if o is greater than 1, the radicals R3 are identical or di...
WO/1995/029171A1	PREPARATION OF ARTHROPODICIDAL OXADIAZINES A method for making arthropodicidal oxadiazines and intermediates which are racemic or enantiomerically enriched at their chiral center, the method for making the oxadiazines comprising reaction of an intermediate selected from (II) or (...
WO/1995/029152A1	BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS This invention relates to new benzamide derivatives having a vasopressin antagonistic activity, etc. and represented by general formula (I), wherein R1 is aryl optionally substituted with lower alkyl, etc., R2 is lower alkyl, etc., R3 is...
WO/1995/028377A1	GUANIDINE COMPOUNDS AS REGULATORS OF NITRIC OXIDE SYNTHASE Guanidine compounds of formula (I) or a pharmaceutically-acceptable salt, ester, amide or prodrug thereof, which are regulators of nitric oxyde synthase and are useful in the treatment of disorders of the vascular system including hypote...
WO/1995/024393A1	NAPHTHALENE DERIVATIVES AS PROSTAGLANDIN I2 AGONISTS A compound of formula (I) wherein, R1 is carboxy or protected carboxy; R2 is hydrogen, hydroxy or protected hydroxy; R3 is hydrogen, hydroxy, protected hydroxy, etc.; R4 is hydrogen or halogen; A1 is lower alkylene; A2 is bond or lower a...
WO/1995/019767A1	GUANYLHYDRAZONES FOR TREATING INFLAMMATORY CONDITIONS This invention concerns new methods and compositions that are useful in preventing and ameliorating cachexia, the clinical syndrome of poor nutritional status and bodily wasting associated with cancer and other chronic diseases. More par...
WO/1995/019960A1	MONOAMINE OXIDASE B INHIBITORS, PROCESSES FOR THEIR PREPARATION AND USE THEREOF Novel monoamine oxidase B inhibitors of formula (I), wherein R1 = H, an optionally substituted benzyloxy or phenylethoxy group; p = 0-3; R3 = H, a CN, OH, CCH group, a C1-C3 alkoxy-carbonyl group, or a C1-C3 alkylated cyanomethyl group; ...
WO/1995/018832A1	NEW POLYAMINOCARBOXYLATE CHELATORS This invention describes a series of novel polyamino-carboxylate chelators suitable for attaching metal ions to polypeptide molecules. Polypeptide-polyaminocarboxylate conjugates prepared using the novel chelators form stable complexes w...
WO/1995/009619A2	SUBSTITUTED UREA AND ISOTHIOUREA DERIVATIVES AS NO SYNTHASE INHIBITORS The use of an N-substituted urea derivative for the manufacture of a medicament for the treatment of a condition where there is an advantage in inhibiting the NO synthase enzyme, in particular cerebral ischemia, and pharmaceutical formul...
WO/1995/007269A1	POLAR-SUBSTITUTED HYDROCARBONS The invention relates to retroviral protease inhibitors of the general formula (I): W-(A)n-B-(A)m-V where W, A, B, A, V, n and m are as defined herein, including related prodrugs of general formula (I) comprising a solubilising group w...
WO/1995/006251A1	COATING OF HYDROPHOBIC SURFACES TO RENDER THEM PROTEIN RESISTANT WHILE PERMITTING COVALENT ATTACHMENT OF SPECIFIC LIGANDS A surface of specific reactivity is formed by adsorbing a modified block polymeric surfactant of the Pluronic-type, i.e., containing pendant poly(ethylene oxide) blocks attached at an end to poly(propylene oxide) center blocks and with s...
WO/1995/004034A1	(THIO)CARBIMIDINIC ACID DERIVATIVES AND MEDICAMENTS CONTAINING THE SAME New medicaments containing (thio)carbamidinic acid derivatives having formula (I) are disclosed, as well as new (thio)carbamidinic acid derivatives, a process for preparing the same and medicaments containing these compounds. Medicaments...
WO/1995/001972A1	HEME BINDING COMPOUNDS AND USE THEREOF Inhibitors of nitric oxide formation from arginine useful for treating hypotension, inflammation, stroke and to restore vascular contractile sensitivity to the effects of alpha1 adrenergic agonists are physiologically active compounds in...
WO/1994/019332A1	RETROVIRAL PROTEASE INHIBITING COMPOUNDS A retroviral protease inhibiting compound of formula (I) is disclosed.
WO/1994/017817A1	INHIBITORS OF THROMBOSIS This invention relates to peptide aldehyde analogs that inhibit the thrombin or Factor Xa. The compounds are thought useful for preventing or treating conditions in mammal characterized by abnormal thrombosis.
WO/1994/011340A1	HYDRAZONE DERIVATIVE A compound representd by general formula (I), a salt thereof, and a pest control agent, wherein: X represents halogen, alkyl, alkoxy, cycloalkyloxy, alkylsulfonyloxy, alkylthio or alkylsulfonyl; R1 represents hydrogen or alkyl; R2 repres...
WO/1994/011490A2	PRODUCTS OF THE INHIBITION OF ADVANCED GLYCOSYLATION A solution of one or two molecules of aminoguanidine or other hydrazine type compound incubated with an Amadori product (1-propylamine-1-deoxy-D-fructose) under physiological conditions proceeds through the reactive intermediate 1-propyl...
WO/1994/008954A1	ARTHROPODICIDAL SEMICARBAZONES Arthropodicidal compounds: I) 2-(2-ethyl-4-fluoro-2,3-dihydro-1H-inden-1-ylidene)-N-[(4-tr ifluoromethoxy)phenyl]hydrazinecarboxamide and II) 2-(5-chloro-2,3-dihydro-2-propyl-1H-inden-1-ylidene)-N-[(4-t rifluoromethoxy)phenyl]hydrazineca...
WO/1994/007815A2	SMALL PEPTIDE ANAPHYLATOXIN RECEPTOR LIGANDS Oligopeptide compounds or oligopeptide analogue compounds of the formula A-B-D are ligands for the anaphylatoxin receptor and are useful in the treatment of inflammatory disease states; also disclosed are anaphylatoxin receptor ligand co...
WO/1994/006758A1	ARYL SEMICARBAZONE ANTICONVULSANTS A number of aryl semicarbazones were prepared as candidate anticonvulsants. When administered orally to rats, significant activity was noted in the maximal electroshock (MES) screen and since neurotoxicity was either absent or reduced (a...

Matches 201 - 250 out of 957	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >