| Document |
Document Title |
|
JP5155864B2 |
The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula (I) as selective 5-HT2c receptor agonists for the treatment of 5-HT2c associated disorders including obesity, obsessive/compulsive disorder, d...
|
|
JP5152895B2 |
|
|
JP5154944B2 |
The present invention is directed to compounds of formula (I) that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present i...
|
|
JP2013505225A |
Process for the synthesis of ivabradine of formula (I): and addition salts thereof with a pharmaceutically acceptable acid.
|
|
JP5140058B2 |
Compounds of the formula I wherein z is SO 2 or SO, useful as metalloproteinase inhibitors, especially as inhibitors of MMP12.
|
|
JP5138592B2 |
Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in the treatment of autoimmunity, inflammation allergy, asthma, graft reject...
|
|
JP2013018780A |
To provide selective 5HT2C agonists which safely decrease food intake and body weight, in the 5HT2C receptor which is a validated and well-accepted receptor target for the treatment of obesity and psychiatric disorders.The present invent...
|
|
JP5129231B2 |
The invention relates to malonamide derivatives of formula wherein A1, A2, R1, R2, R3, and R4 are as defined herein and to pharmaceutically acceptable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures ...
|
|
JP2013010733A |
To provide processes for production of a hemiaminal compound (1) and a cyanoamine compound (4) with excellent yields.A process for production of the hemiaminal compound (1) includes the step A, and a process for production of the cyanoam...
|
|
JP2013010734A |
To provide a new method for producing an N-substituted lactam compound with high yield without requiring special equipment.This method for producing the N-substituted lactam compound (3) includes a step of reacting a lactone compound (1)...
|
|
JP2013501766A |
The present invention relates to the use of a compound of formula (Ia) as a reagent for linking a compound of formula R 1 -H which comprises a first functional moiety of formula F 1 to a second functional moiety of formula F 2 wherein X,...
|
|
JP5118696B2 |
The present invention belongs to pharmaceutical field. It relates to a novel family of bivalent (-)-meptazinol compounds and/or their salts, as well as the preparation and utilization of the compounds in the treatment of neurodegenerativ...
|
|
JP2013500320A |
Ester derivatives of 2-amino-2-phenyl-alkanol of general formula (I) in which: R1 forms with R3 and the nitrogen and carbon atoms to which they are respectively attached, a heterocycle with 4 to 7 members, optionally substituted in the a...
|
|
JP5106562B2 |
|
|
JP5108777B2 |
The present invention discloses an optically active quarternary ammonium salt having axial asymmetry and a method for producing an α-amino acid and a derivative thereof using the same. The optically active quarternary ammonium salt havi...
|
|
JP5107382B2 |
Preparing tetrahydro-benzo[d]azepin-2-one compounds (A) comprises: reacting 3-(7,8-dimethoxy-2-oxo-1,2,4,5-tetrahydro-benzo[d]azepin-3-y
l)-propionitrile (VIII) with (3,4-dimethoxy-bicyclo[4.2.0]octa-1(6),2,4-trien-7-ylmethyl)
-methyl-am...
|
|
JP5106607B2 |
The present invention provides a catalyst composition for preparing an amide, including an amino acid ionic liquid having a cation of formula (1) and an anion selected from the group consisting of an inorganic acid group, an organic acid...
|
|
JP5107381B2 |
Preparing 3-{3-[(3,4-dimethoxy-bicyclo[4.2.0]octa-1(6),2,4-trien-7-ylm
ethyl)-methyl-amino]-propyl}-7,8-dimethoxy-1,3,4,5-tetrahydr
o-benzo[d]azepin-2-one (VIII) comprises: reacting 3,4-dimethoxy-bicyclo[4.2.0]octa-1(6),2,4-triene-7-carb...
|
|
JP5101486B2 |
The invention relates to the field of production of lactams from aminonitriles, and in particular to the production of epsilon-caprolactam by the vapor phase hydrolytic cyclization of 6-aminocapronitrile. A crude liquid caprolactam compr...
|
|
JP5098011B2 |
To provide a wound-healing accelerator having an effect of accelerating the regeneration capacity of a living body by cell migration. This wound-healing accelerator contains a 2-benzazepine derivative expressed by general formula (I) and...
|
|
JP2012232999A |
To provide compounds for use in treating or preventing cognitive disorders, such as Alzheimer's Disease.N-substituted benzenesulfonamides are expressed by the following formula (I) (wherein R1 is aryl alkyl, arylalkenyl or arylalkynyl; R...
|
|
JP5081363B2 |
The invention relates to benzofuran or benzothiophene derivatives, to processes for preparing them, to pharmaceutical compositions comprising them, and to the method of use thereof in the treatment of pathological syndromes of the cardio...
|
|
JP2012525347A |
A method for preparing lactams by cyclizing hydrolysis of a corresponding aminonitrile is described. A method for manufacturing a lactam by reacting an aminonitrile with water in the presence of a catalyst involving placing the water and...
|
|
JP2012197296A |
To provide a process for producing a benzoazepine compound or a salt thereof in a high yield and in a high purity, and industrially advantageously.A benzoazepine compound represented by formula (10) or a salt thereof is produced by reduc...
|
|
JP5046587B2 |
This invention provides a process for preparing benzazepine compounds of the formula (1): wherein X 1 is a halogen atom, R 1 and R 2 are a lower alkyl group, or salts thereof as well as intermediate benzoic acid compounds in high yield a...
|
|
JP2012183532A |
To provide apparatus, systems and methods that utilize microreactor technology to achieve desired mixing and interaction at a micro and/or molecular level between and among feed stream constituents.Feed streams are fed to an intensifier ...
|
|
JP5037336B2 |
Novel cyclohexyl-1,4-diamine compounds corresponding to formula I processes for preparing such compounds, pharmaceutical formulations comprising these compounds, methods of making such pharmaceutical formulations and the related methods ...
|
|
JP2012522042A |
Disclosed are novel organic electroluminescent compounds and organic electroluminescent devices comprising the same. With good luminous efficiency and excellent life property, the disclosed organic electroluminescent compounds can be use...
|
|
JP2012176979A |
To provide 7-chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoylamino)benzo
yl]-2,3,4,5-tetra-hydro-1H-1-benzazepine in high purity or a salt thereof.There are provided 7-chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoylamino)benzo
yl]-2,3,4,5...
|
|
JP5021752B2 |
The present invention relates to novel compounds of general formula (I) which are thyroid receptor ligands and are preferably selective for the thyroid hormone receptor beta (TR-Beta). Further, the present invention relates to processes ...
|
|
JP5017103B2 |
The present invention comprises pharmaceutical compositions comprising a co-crystal of an API and a co-crystal former, and methods of making and using the same.
|
|
JP5016234B2 |
To provide a method of depolymerizing a polyamide, whereby depolymerization of a polyamide is carried out without causing corrosion in a metallic apparatus; and to provide a production method for a monomer of a polyamide. The method of d...
|
|
JP5014792B2 |
The invention relates to a process for preparing caprolactam by admixture of cyclohexanone oxime to a reaction mixture comprising caprolactam and sulfuric acid using a mixing device, said mixing device comprising (i) a tube through which...
|
|
JP5014791B2 |
The invention relates to a process for preparing caprolactam by admixture of cyclohexanone oxime to a reaction mixture comprising caprolactam and sulfuric acid using a mixing device, said mixing device comprising (i) a tube through which...
|
|
JP2012158501A |
To provide a method for producing zeolite excellent in catalytic activity and catalyst life, and to provide a method for stably producing ε-caprolactam over a long period of time by reacting cyclohexanone oxime at a high conversion rati...
|
|
JP5005162B2 |
The present invention provides an efficient synthetic process for making benazepril and analogues thereof by having an intermediate compound undergo epimerization and kinetic resolution.
|
|
JP5008553B2 |
The present invention provides a chiral phase-transfer catalyst of the following formula (I): The compound (I) can be produced by reacting a 2,2'-dimethylene bromide-1,1'-biphenyl derivative, which can be produced through comparatively s...
|
|
JP4991532B2 |
Benzoyl urea derivatives that are alpha helical peptide mimetics that mimic BH3-only proteins, compositions containing them, their conjugation to cell-targeting moieties, and their use in the regulation of cell death are disclosed. The b...
|
|
JP4991540B2 |
The invention provides compounds, compositions and uses of compounds of general formula (I) or pharmaceutically acceptable salts thereof, which are 3-aminocaprolactam derivatives, for the preparation of a medicament intended to treat an ...
|
|
JP2012140444A |
To provide 3-aminocaprolactam derivatives for preparation of a medicament intended to treat an inflammatory disorder.There are provided the compounds represented by general formula (I) (wherein X is -CO-Y-(R1)n or SO2-Y-(R1)n; and Y is c...
|
|
JP4987894B2 |
In the production of µ-caprolactam by contacting cyclohexanone oxime with a solid acid catalyst in the gaseous phase to effect a rearrangement reaction of the cyclohexanone oxime, wherein the solid acid catalyst is produced by calcining...
|
|
JP4983041B2 |
|
|
JP4982184B2 |
The invention relates to tetrahydrobenzazepines of the general formula I in which the variables Ar, A, B, Y, R1 and R2 have the meanings indicated in claim 1, as well as the N-oxides of these compounds, the physiologically tolerated acid...
|
|
JP4981222B2 |
|
|
JP4966929B2 |
The present relation relates to 8-chloro-1-methyl-2,3,4,5-tetrahydro-1 H -3-benzazepine or a pharmaceutically acceptable salt, solvate, or hydrate thereof for the treatment of a disorder of the central nervous system selected from: depre...
|
|
JP4969722B2 |
The present invention relates to a process for the preparation of zeolitic catalysts comprising zeolite and oligomeric silica, which can be used in industrial reactors. The process consists in directly mixing the suspension, resulting fr...
|
|
JP2012514654A |
Fluorinated compounds and methods of making fluorinated compounds are described herein.
|
|
JP2012514655A |
Fluorinated compounds and methods of making fluorinated compounds are described herein.
|
|
JP4961209B2 |
Method for making caprolactam from 6-aminocapronitrile that contains greater than 500 ppm tetrahydroazepine and its derivatives (THA) in which the THA is not removed from the method until after the caprolactam is produced.
|
|
JP4961208B2 |
Method for making caprolactam from 6-aminocapronitrile that contains greater than 500 ppm tetrahydroazepine and its derivatives (THA) in which ammonia and water are removed from crude caprolactam in a single separation step and then THA ...
|
