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Matches 1 - 50 out of 20,194

Document Document Title
WO/2024/037485A1
The present invention relates to a preparation method for an amorphous form of the compound of formula I. Specifically, the present invention provides a preparation method for an amorphous form of letermovir, the compound of formula I. T...  
WO/2024/037520A1
Disclosed in the present invention are a new compound as represented by general formula I, a pharmaceutically acceptable salt, an enantiomer, a diastereoisomer and a racemate thereof, and a pharmaceutical composition containing the compo...  
WO/2024/037668A1
Disclosed are a 2-nitrogen-substituted pyrimidine compound represented by formula I, a respective optical isomer, a deuterated substance, a prodrug or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising th...  
WO/2024/032597A1
A compound having a STING inhibitory effect or a pharmaceutically acceptable salt thereof, and a use thereof in the preparation of a drug for treating diseases related to abnormal STING expression. Specifically disclosed are compounds of...  
WO/2024/035688A1
Described are the compounds, compositions and methods of treating diseases and disorders that involve aberrant B-cell lymphoma 6 (BCL6) activity.  
WO/2024/031242A1
A method for synthesizing an aryl benzyl thioether compound using photocatalysis. By using the iron (III) complex [HIMXy Me][FeBr 4]([HIMXy Me]=l,3-bis(4-methoxy-2,6-dimethylphenyl)-4,5-dimethylimidaz olium cation) as a catalyst, fac-Ir(...  
WO/2024/035921A1
This disclosure relates to compounds which are degraders of son of sevenless homolog 1 (SOS1) and their use in treating cancers, in particular KRAS-mutant cancers.  
WO/2024/027767A1
The present invention relates to a herbicide composition comprising a uracil compound comprising at least one carboxylate fragment represented by formula (I) and at least one herbicide active compound, and a use of the herbicide composit...  
WO/2024/030429A1
Various novel nucleoside analogs described herein have the promise of achieving higher efficiency against a variety of viral infections, including the dangerous respiratory ones, like SARS-CoV-2 and COVID-19, as well as lower incidence a...  
WO/2024/027814A1
Disclosed are a compound as represented by formula (I) having a KRas G12D inhibitory effect, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, and the use thereof in the preparation of a drug for KRas G12D-related...  
WO/2024/030651A1
The present disclosure provides a compound of Formula (I'), or a pharmaceutically acceptable salt thereof and its use in, e.g. treating a condition, disease, or disorder in which inhibiting GPX4 in a subject is of therapeutic benefit, sp...  
WO/2024/027765A1
The present invention relates to the field of pesticides and herbicides, in particular to a method for preparing compound 2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)- 3,6-dihydropyrimidin-1(2H)-yl)benzoate of formula (I)....  
WO/2024/025991A1
A method is disclosed of detecting a disease associated with pulmonary vascular remodeling in a subject. The method can comprise administering to the subject a compound of Formula I or Formula II. The method can further comprise imaging ...  
WO/2024/022998A1
The present invention provides crystal forms of daprodustat, which are cocrystals comprising daprodustat free acid and a daprodustat pharmaceutically acceptable metal salt, wherein the metal salt is an alkali metal salt. The invention al...  
WO/2024/026424A1
The present disclosure relates to compounds of Formula (I) and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are usefu...  
WO/2024/020170A1
Provided herein are compounds which can act agonists of the aryl hydrocarbon receptor (AHR). Further disclosed herein are methods for treating inflammatory and autoimmune diseases and disorders, such as diseases or disorders of the gastr...  
WO/2024/018394A1
The present invention relates to a process for the preparation of crystalline form A of N, N'-bis(2-aminoethyl)-1,2-ethanediamine tetrahydrochloride (I).  
WO/2024/017251A1
The present disclosure relates to a macrocycle for inhibiting and inducing EGFR degradation and a preparation method for and a use of the macrocycle. Specifically, the present disclosure relates to a macrocycle as shown in general formul...  
WO/2024/017258A1
Disclosed in the present invention are a multi-target small molecule inhibitor, a pharmaceutical composition containing same, and a use thereof. Specifically, the compound of the present invention has a structure as shown in formula (I)....  
WO/2024/011414A1
Disclosed in the present invention is a reaction method for secondary amine and o-diiodobenzene, comprising: reacting secondary amine with o-diiodobenzene in the presence of an alkali metal hydride or a Grignard reagent to complete the r...  
WO/2024/014303A1
Provided is a compound represented by formula (1).  
WO/2024/012554A1
The present disclosure belongs to the field of biomedicine, and specifically relates to a method for preventing or treating neurodegenerative diseases or alleviating symptoms of neurodegenerative diseases. Said method comprises administe...  
WO/2024/015918A2
The present disclosure provides novel chemotypes, pharmaceutical compositions thereof, and method of use thereof for treating parasitic infection, including infection caused by parasitic flatworms. The present compounds may be useful as ...  
WO/2024/010015A1
Compounds represented by general formula (1), the compounds having strong inhibitory action against mPGES-1 and being useful as active ingredients for pharmaceuticals for the treatment of inflammation and the like.  
WO/2024/010782A1
Disclosed are compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof, wherein R1, R3, X, Y, Z, and W arc as defined herein. The compounds are, for example, inhibitors of WRN helicase and useful in treating a pr...  
WO/2024/011075A2
A light delivery device for delivering light therapy includes a light source configured to emit light, one or more first piercing members extending from a distal surface of the light delivery device, the one or more first piercing member...  
WO/2024/009691A1
The present invention provides: a nonaqueous electrolyte solution which comprises (I) at least one compound that is selected from the group consisting of compounds represented by general formula (1), compounds represented by general form...  
WO/2024/008191A1
Provided are a quinazolinedione-containing compound with a structure represented by formula (I), a method for preparing same, and use thereof. The compound has excellent herbicidal activity against weeds in bulk crops such as rice and wh...  
WO/2024/003535A2
Disclosed are compounds of the formula (I), or a tautomeric form thereof, or a pharmaceutically acceptable salt or N-oxide thereof: (I) wherein R1, R2, R3, R4, R5, n, m, and x are as defined herein. Compounds of the invention may be suit...  
WO/2024/000401A1
The present invention relates to compounds of formula (I) preferred compounds are e.g. 2-((l-(4-oxo-3,4-dihydroquinazolin-8-yl)ethyl)amino)benzoic acid derivatives of formula (ll-A) an exemplary compound is e.g. 2-((l-(2-(isoindolin-2-yl...  
WO/2024/003259A1
The present invention covers heterocyclic compounds of general formula (I): Formula (I), wherein (I'), Formula (I') represents a heterocyclic ring, said compound of general formula (I) being selected from the group consisting of: Formula...  
WO/2023/247563A1
A compound of formula (I-A), R1 in each occurrence is selected from H, optionally substituted C1-12 alkyl and optionally substituted C6-20 aryl; R2 in each occurrence is selected from optionally substituted C1-12 alkyl and optionally sub...  
WO/2023/249970A1
The present disclosure provides certain bifunctional compounds containing pyrimidine deriviatives that cause degradation of Cyclin-dependent kinase 2 (CDK2) via ubiquitin proteasome pathway and are therefore useful for the treatment of d...  
WO/2023/244639A1
The present disclosure relates to methods of treating cancer in a subject, comprising analyzing one or more biological sample(s) for the presence of a first genetic marker and administering an EGFR inhibitor to the subject if the presenc...  
WO/2023/243677A1
The present invention provides a plant disease control method having an excellent efficacy for controlling plant diseases, the method comprising treating plants or soil used for plant cultivation with a compound represented by formula (I...  
WO/2023/244599A1
The present invention relates to compounds that inhibit at least one of KRas G12A, KRas G12C, KRas G12D, KRas G12R, KRas G12S, KRas G12V, KRas G13D and KRas Q61H, pharmaceutical compositions comprising the compounds and methods of use th...  
WO/2023/241608A1
The present application relates to compounds of formula (I) and formula (1'), which are useful as inhibitors of CSF-1R in the treatment of various diseases.  
WO/2023/244713A1
The invention provides novel quinazoline derivatives, substituted at the C4 position with an unsubstituted or substituted, 3- to 10-membered monocyclic, bicyclic or bridged nitrogen heterocyclic ring moiety, that are shown to be potent a...  
WO/2023/239675A1
The present disclosure is related to STING agonists, pharmaceutical compositions thereof, and the use of the agonists and pharmaceutical compositions to induce a STING-mediated immune response and/or to treat diseases and disorders media...  
WO/2023/236752A1
Disclosed in the present invention are a heterocyclic derivative having a structure as shown in formula (I), or a stereoisomer and a pharmaceutically acceptable salt thereof. The heterocyclic derivative or the stereoisomer thereof has hi...  
WO/2023/240084A2
The present disclosure relates generally to small molecule inhibitors of Sterile Alpha and TIR Motif containing 1 (SARM1) protein, or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomer...  
WO/2023/239710A1
Novel PI3K inhibitors of the general Formula (1) are described along with methods of their preparation and their use in the treatment of diseases associated with the elevation or activation of the PI3K pathway, wherein R1 to R8 are as de...  
WO/2023/231826A1
Disclosed in the present invention are a letermovir intermediate compound, and a preparation method and application thereof. In particular, disclosed are compounds (II), (III) and (IV), and the structures of the compounds are shown below...  
WO/2023/232507A1
A process for increasing the yield of a process for the preparation of Compound (I), in which Compound (I) is obtained in solubilized form in an organic solvent phase, crystallized and separated from the mother liquor, comprising (I) STE...  
WO/2023/230500A1
In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure, in one aspect, relates to compounds (I) that are inhibitors for spleen tyrosine kinase (Syk), which is a key signaling...  
WO/2023/226920A1
Provided herein are novel compounds (e.g., Formula I or II), pharmaceutical compositions, and methods of using related to cyclin dependent kinases (CDKs). The compounds herein are typically CDK inhibitors, which can be used for treating ...  
WO/2023/227721A1
The present invention concerns novel crystalline forms of aprocitentan sodium salt, processes for the preparation thereof, pharmaceutical compositions comprising said crystalline forms, pharmaceutical compositions prepared from such crys...  
WO/2023/229293A1
The present invention relates a bicycle derivative and a pharmaceutical composition comprising same as an active ingredient for the prevention or treatment of cancer. Found to have ACC inhibitory activity involved in the inhibitory mecha...  
WO/2023/226456A1
The present invention relates to a method for preparing azoxystrobin. In the method of the present invention, azoxystrobin is prepared under catalysis by using a pentacyclozole compound or a salt thereof as a catalyst, wherein the pentac...  
WO/2023/226323A1
The present invention relates to the technical field of chemical medicine, and in particular to a quinazoline derivative, and a preparation method therefor and the use thereof. The quinazoline derivative provided by the present invention...  

Matches 1 - 50 out of 20,194