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WO/1996/039193A2 |
The invention relates to novel targeting drug agents that are targeted for entry into the mitochondria. More specifically, the agents are cisplatin derivatives called mitoplatins which are useful as anti-tumor agents. Mitoplatins are nam...
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WO/1996/034825A1 |
An intercalation compound of general formula (I) is described Nax K1-x Zy, wherein Z is a carbon or a polymer with a cyclic, particularly aromatic unit, for example a polymer with C6H4 as base unit; 0 < x < 1, and 2 y 6, where Y may or m...
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WO/1996/031435A1 |
Disclosed is a process for purifying a cesium compound which includes an ionic impurity comprising: calcium, sulfate, magnesium or mixtures thereof comprising: reacting impurities comprising calcium, sulfate, magnesium or mixtures thereo...
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WO/1996/029753A1 |
The present invention relates to metal ion salts which can be used in electrolytes for producing electrochemical devices, including both primary and secondary batteries, photoelectrochemical cells and electrochromic displays. The salts h...
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WO/1996/028449A1 |
Porphyrazine compounds having moieties substituted at the eight peripheral 'beta'-pyrrole positions are disclosed. The porphyrazine compounds have general structural formula (V), wherein M is H2 or a metal capable of complexing with the ...
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WO/1996/027598A1 |
A method of stereoselectively preparing a 'beta'-benzyl substituted carbonyl compound of general formula (3), in which R6 is selected from aryl and substituted aryl and R7 is a chiral auxiliary, includes reacting an 'alpha','beta'-unsatu...
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WO/1996/013504A1 |
A 'beta','beta''-dihydroxy meso-substituted chlorin, bacteriochlorin or isobacteriochlorin compound having formula (I) or (II), wherein M is a metal. A novel method for synthesizing the compound of formula (I) or (II) comprises the steps...
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WO/1996/008311A1 |
The present invention provides a novel synthesis for preparing D4-symmetric chiral porphyrins derived from 1R-(+)-nopinone. The simplicity and flexibility of this synthetic protocol provides an attractive route to this novel class of por...
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WO/1996/006101A1 |
A palatable metal amino acid chelate for administration to humans and other warm-blooded animals is disclosed wherein there are sufficient ligands to provide ionic and coordinate covalent bonds equal to the coordination number of the cen...
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WO/1995/032192A1 |
The present invention provides aromatic amine substituted metal chelating compounds of formula (I) in which the variables are as defined in the claims, chelates and chelate-targeting moiety conjugates formed from the chelating compounds,...
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WO/1995/032249A1 |
The invention is a dye composition containing two or more dyes of the vinyl sulfone type which can be used in combination to dye polyamide substrates. Preferably the dye compositions of the invention contain at least three dyes of differ...
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WO/1995/031425A1 |
The invention includes the synthesis of multivalent metal complexes with boron containing complex organic anions. The complexes include or may include ligands. Complexes capable of being so synthesised are also disclosed as is their use ...
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WO/1995/030681A1 |
Single or multi-nuclear metal complexes [LnMmXp]zY, in which M is manganese in the oxidation number (II, III, IV, V and/or VI), copper in the oxidation number (I and/or II), cobalt in the oxidation number (II and/or III) or zinc in the o...
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WO/1995/028179A1 |
Paramagnetic metal complexes of 1-(p-n-butylbenzyl)diethylenetriamine pentaacetic acid and pharmaceutically acceptable salts thereof are effective as tissue-specific MRI contrast agents, and in particular as hepatobiliary MRI contrast ag...
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WO/1995/023803A1 |
A process for quickly preparing easily separable solutions of lithium alkylamides, as exemplified by the formula (I): (R3M)xNLi(R1)y.(LB)z wherein M is silicon or carbon, R and R1 are C1-C8 alkyl, cycloalkyl or alkylene groups, LB is a L...
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WO/1995/022905A1 |
The present invention relates to a process for producing a gel-free dispersion or solution of copper pyrithione by an ion-exchange reaction using a reaction mixture of a copper salt and a pyrithione salt in the presence of at least one s...
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WO/1995/022566A1 |
A process for the preparation of hydrocarbon solutions of monofunctional ether initiators of the following general structure: M-Z-O-C(R1R2R3) wherein M is defined as an alkali metal, preferably lithium; Z is defined as a branched or stra...
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WO/1995/018134A1 |
Novel compounds of general formula (I) (wherein R represents a carbocyclic aryl group, R1 represents an organic group, R2 represents a hydrogen atom or an organic group, and the asterisk denotes that the group R1 is predominantly in the ...
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WO/1995/005150A1 |
Hydroxy salts of the formula [M(OH)(2-a)]a+ Xb-a/b . zH2O, where M is zinc, copper or a mixture of the two and X denotes anions at least some of which display ultraviolet absorption over at least a portion of the wavelength range from 29...
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WO/1995/004114A1 |
Tris(isonitrile)copper(I) sulfate complexes and their use in synthetic methods for making radionuclide isonitrile coordination complexes such as [99mTc(1-isocyano-2-methoxy-2-methylpropane)6]+. The coordination complexes are useful as ra...
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WO/1995/001982A1 |
A high temperature process for producing alkyllithium compounds in high yields of at least 90 % and high purity comprising reacting, in a liquid hydrocarbon solvent, an alkyl halide containing 3 to 16 carbon atoms and mixtures thereof wi...
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WO/1994/027988A1 |
The novel optically pure compounds Na+, Mg2+, Li+, K+, Ca2+ and N+(R)4 salts of (+)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl
]sulfinyl]-1H_-benzimidazole or (-)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl
]su...
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WO/1994/022877A1 |
A general method for sequential addition of two substituents to an alpha,beta-unsaturated ketone (enone), involving 1,4-conjugate addition of a desired substituent group to the enone to form an intermediate enolate, followed by electroph...
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WO/1994/011787A1 |
There is described a method of chemically depositing a substance. The method is of utility in the direct manufacture of integrated circuits and in the manufacture of a photomask for use in production of integrated circuits. The method in...
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WO/1994/008949A2 |
The invention concerns novel metal chelating compounds, and radiometal, e.g. technetium-99m complexes thereof. The compounds can be used to radiolabel small biologically active species with minimal effect on their biodistribution and act...
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WO/1994/004141A1 |
Vitamin and mineral absorption in warm-blooded animals is promoted by means of a class of vitamin chelates where at least one of the bonds between the metal ion and the vitamin ligand is formed between the ion and an electron rich pi-clo...
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WO/1993/024263A1 |
Novel zerovalent metal species and organometallic reagents are disclosed. The zerovalent metal species are directly produced by reaction of a reducing agent on a metal cyanide salt. Preferably, the zerovalent metal species are directly p...
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WO/1993/020120A2 |
The present invention relates to a novel compound, its use as an initiator in anionic polymerizations yielding norbornene-terminated homopolymers of block copolymers, and the further use of said norbornene-terminated polymers as macromon...
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WO/1993/020088A1 |
Mixed ligand metal complexes of nitric oxide-nucleophile adducts, useful as cardiovascular agents of the formula KA, wherein A is [(M)x'x(L)y(R1R2N-N2O2)z], and M is a pharmaceutilcally acceptable metal, or where x is at least two, M may...
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WO/1993/015770A1 |
The present invention relates to novel ligands and labelling techniques. The present invention further relates to a diagnostic composition suitable for administration to a warm-blooded animal comprising somatostatin or hirudin or a molec...
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WO/1993/015771A1 |
Amide-thiolate ligands having improved metal chelate formation kinetics are disclosed. The ligands include an amine to facilitate rapid formation of an amine-amide-thiolate intermediate complex, followed by transfer of the metal to or co...
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WO/1993/011135A1 |
The present invention relates to processes for preparing sunscreen complexes, and more particularly to sunscreen metal complexes, having enhanced UVA absorption. These complexes comprise a dibenzoylmethane UVA-absorbing sunscreen complex...
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WO/1993/007140A1 |
Compounds of formula (I), wherein ring A, ring B, ring D, R2, R3, R4, R5, R6, R11, R12, R13, E, G, X and P are as defined below. The compounds of formula (I) are cholinesterase inhibitors and are useful in enhancing memory in patients su...
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WO/1992/020764A1 |
This invention relates to copper-containing organometallic complexes, and to concentrates and diesel fuels containing said complexes. The diesel fuels are useful with diesel engines equipped with exhaust system particulate traps. The cop...
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WO/1992/019622A1 |
A process for producing high purity stable etherical solutions of aryllithium compounds by reacting lithium metal, in the form of a dispersion, with a monohaloaryl compound in an ether of the formula ROR' wherein R and R' are independent...
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WO/1992/019623A1 |
A novel zerovalent copper species and an organocopper reagent are disclosed. The zerovalent copper species is directly produced by reaction of a reducing agent with a combination of copper cyanide or halide and an alkali metal halide sal...
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WO/1992/009609A1 |
A process for the preparation of alkyllithium compounds including 2-alkyl-substituted alkyllithium compounds by reacting in a liquid organic solvent, in an inert atmosphere a C¿2? to C¿18? saturated, acyclic, primary alkyl halide inclu...
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WO/1992/007971A1 |
Chemical vapor deposition precursors for depositing copper, silver, rhodium and iridium metals on substrates comprise ligand stabilized +1 metal beta-diketonate coordination complexes of said metals. Uses of such precursors in CVD proces...
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WO/1991/019720A1 |
Nitrogen and silver containing derivative in which a substituted or not substituted aliphatic or aromatic group is attached via a carbonyl radical, possibly followed by at least a carbon atom and/or aromatic or aliphatic ring, to an amin...
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WO/1991/019978A1 |
Method using tetra-aryl porphyrins for and, in particular, 5,10,15,20-tetrakis(4-carboxyphenyl)porphine as a fluorescent tracer for cancers of the lung, and as a radiotracer therefor as a complex with 67Cu. The latter complex also provid...
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WO/1991/019516A1 |
The invention relates to a metal-radionuclide complex comprising isonitrile ligands, said complex having general formula (I), wherein M is a metal-radionuclide selected from radioisotopes of Tc, Ru, Fe, Cr, Mn, Cu, Pb, Ga, As and In; R1 ...
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WO/1991/019977A1 |
Method using tetra-aryl porphyrins for and, in particular, 5,10,15,20-tetrakis(4-carboxyphenyl)porphine as a fluorescent tracer for cancers of the lung, and as a radiotracer therefor as a complex with 67Cu. The latter complex also provid...
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WO/1991/017167A1 |
Dialkyl gold (III) beta-diketonates are synthesized in a two-step, one-pot process using a gold trihalide, an alkyl lithium compound and a beta-diketone.
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WO/1991/015493A1 |
Higher order cuprate complexes are prepared by means of a transmetalation from a corresponding zirconate intermediate. This process is particularly valuable with respect to the preparation of vinylic side chains such as are present in pr...
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WO/1991/014459A1 |
The subject matter of the present invention relates to bifunctional cyclohexyl DTPA ligands and methods for utilizing these compounds.
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WO/1991/013892A1 |
The invention relates to a new organic derivative of a metal, characterized in that it consists of a derivative of a metal, preferably with a valency of at least 3, with an organic compound comprising a phospholipid which renders the org...
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WO/1991/011494A1 |
An organometallic composition containing copper (I) comprising an organometallic composition of formula: RTRRCuLi, characterized in that RT is a transferable anionic group, RR is a residual anionic group and containing 0.01 to 1.2 mole e...
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WO/1991/003261A1 |
Novel magnetic resonance imaging agents comprise complexes of paramagnetic ions with aminoalkylamide derivatives of diethylenetriaminepentaacetic acid (''DTPA'') or ethylenediaminetetraacetic acid (''EDTA'') or other polyaminocarboxylic ...
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WO/1990/014881A2 |
A new series of bifunctional chelating agents useful for attaching metal ions to proteins, polypeptides and other polymers and methods for their preparation are described. These reagents are unique in their ability to bind a variety of m...
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WO/1990/002781A1 |
An organometallic composition containing copper (I) comprising: an organometallic composition of the formula RTRRCuLi characterized in that RT is a transferable anionic group, RR is a residual anionic group and containing 0.01 to 1.2 mol...
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