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JP2009120840A |
To provide a process for treating an oil derived from microorganisms.This process for treating an oil comprises bringing the oil into contact with a polar solvent to extract at least one compound that is soluble in the solvent, and then ...
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JP4269110B2 |
The invention provides an improved process for the preparation of 17-esters of 9 alpha ,21-dihalo-pregnane-11 beta ,17 alpha -diol-20-ones, and in particular for the preparation of 17-esters of anti-inflammatory steroids according to the...
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JP4263479B2 |
This invention relates to a process for the production of 4-(17alpha-alkoxymethyl-17beta-substituted-3-oxoestra-4,9-di
en-11beta-yl)benzaldehyde-(1E)-oxime derivatives of general formula (I) in which R means an amino group, an O-C1-7-alk...
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JP4263478B2 |
The invention relates to a method for the production of 4-(17alpha substituted 3-oxoestra-4,9-dien-11beta-yl)benzaldehyd-(1E or 1Z)-oximes of general formula (I), where R1-H, C1-6 alkyl or a CnF2n+1 group; R2-C1-4 alkyl, X=E- or Z-OH; an...
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JP4257117B2 |
An improved process for preparing steriods, such as 3-oxo-4-azasteroids, is described. Compounds of this type are known to be useful in the preparation of compounds having 5a-reductase inhibitor activity. The process comprises the hydrog...
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JP4234799B2 |
1- or 6-hydroxylated steroids of formula (I) are new. Either R1 = H and R2 = OR6; or R1 = OR6 and R2 = H; R5, R6 = H or 1-12C acyl (optionally substituted by one or more halo); R3 = 1-12C alkyl; R4 = 1-4C alkyl; wavy lines indicate that ...
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JP4233504B2 |
The object of the present invention is to provide vitamin D derivatives that have excellent physiological activities as medicines, particularly as therapeutic agents for skin diseases such as psoriasis, and that have a reduced hypercalce...
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JP4226552B2 |
This invention relates to a method for selectively preparing the 3-oxo-4-aza-5¥á-androstane compound which is used as an intermediate of finasteride by heating 3-oxo-4-aza-5-androstene in a mixture of formic acid and an alkanediol in t...
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JP4210437B2 |
According to the present invention, there is provided a process for enzymatically producing dietary sterol fatty acid esters having physiological activities from phytosterols and fatty acids or oils and fats using lipase as a catalyst; t...
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JP2008546694A |
A mutual prodrug of a corticosteroid and a substituted phenylphosphate (β-agonist derivative) for formulation for delivery by aerosolization to inhibit pulmonary inflammation and bronchoconstriction is described. The mutual prodrug is p...
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JP4177897B2 |
PCT No. PCT/FI97/00170 Sec. 371 Date Sep. 15, 1998 Sec. 102(e) Date Sep. 15, 1998 PCT Filed Mar. 14, 1997 PCT Pub. No. WO97/34917 PCT Pub. Date Sep. 25, 1997The invention relates to a process for catalytic hydrogenation of non-hormonal u...
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JP4146897B2 |
Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of Formula I wherein: -A-A- represents the group -CHR4-CHR5- or CR4-CR5- R3, R4 and R5 are ...
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JP2008534638A |
There are provided crystalline particles of unsolvated Form 1 polymorph of the compound of formula (I): characterised in that the particles are in the form of substantially triangular plates.
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JP4125788B2 |
Recovery of a phenolics-depleted natural mixture of conjugated oestrogens from the urine of pregnant mares comprises (a) providing a liquid urine (which comprises a urine freed from mucous and solids, a concentrate of the latter or a uri...
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JP2008522983A |
The invention encompasses processes for synthesizing 1-[17²-acetyloxy-3±-hydroxy-2²-(4-morpholinyl)-5±-andros
tan-16²-yl]-1-(2-propenyl)pyrrolidinim bromide (rocuronium bromide) and intermediates thereof.
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JP4095018B2 |
A process for the preparation of high purity flumethasone in high yield involves C3 protecting 9,11beta-epoxy-17alpha,21-dihydroxy-16alpha-methylpregna-1,4
-diene-3,20-dione,21-acetate, fluorinating at 6alpha, removing the C3 protecting ...
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JP4076097B2 |
A process for preparing the compound (11beta,16beta)-21-(3-CARBOXY-1-OXOPROPOXY)-11-HYDROXY-2'-ME
THYL-5'H-PREGNA-1,4-DIENO(17,16-D) OXAZOLE-3,20-DIONE which comprises reacting the compound (11beta,16beta)-11,21-DIHYDROXY-2'-METHYL-5'H-P...
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JP4070463B2 |
A method of producing 3-alkoxy-1,3,5(10)-triene-6-one-steroid derivatives having, in the steroid skeleton thereof, a partial structure of A- and B-rings represented by formula (2) : (wherein R represents an alkyl group, a cycloalkyl grou...
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JPWO2005095432A1 |
The present invention selectively reduces the carbon-carbon double bond of the 5α-pregnane derivative represented by the general formula (II) in the mixture of the 5α-pregnane derivative represented by the general formula (I) and the g...
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JP2007326855A |
To provide a new material useful as an antitumor agent, a cardiotonic drug and an anticancer agent-sensitive enhancer, and a production method of the material from a plant. The new steroid-type cardiotonic glycoside represented by genera...
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JP4016070B2 |
PCT No. PCT/EP96/05390 Sec. 371 Date Jun. 5, 1998 Sec. 102(e) Date Jun. 5, 1998 PCT Filed Dec. 4, 1996 PCT Pub. No. WO97/21722 PCT Pub. Date Jun. 19, 1997A process for preparing the compound (11 beta ,16 beta )-21-(acetyloxy)-11-hydroxy-...
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JP4015206B2 |
A process for the production of medrogestone, in which, in an intermediate step, the solvate 3β,5α,6β-trihydroxy-6α,17α-dimethylpregnan-20-one monomethanolate is obtained as a solid, stable compound by displacing the organic solvent...
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JP2007530557A |
Processes are described for epoxidation reactions. In particular, the process comprises the conversion of a steroid substrate having an olefinic unsaturation in the steroid nucleus to a structure comprising a 9,11-epoxy substituent by re...
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JP4002438B2 |
The present invention concerns with steroid compounds of formula (I) wherein R<1> is cyclyhexyl or cycloheptyl, R<2> is hydrogen or C1-C6 alkyl, R<3> is hydrogen, C1-C6 alkyl or methylol, R<4> is hydrogen or hydroxymethylene and a pharma...
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JP2007269815A |
To provide a compound useful as an agonist for FXR (Farsnesoid X receptor), a preparation containing such the compound, and use thereof on the therapy. The compound useful as the agonist to the FXR is a compound of formula (I) (wherein, ...
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JP3986313B2 |
This invention discloses a novel method for the conversion of carboxylic acids to carbothioic acids and application of the method to the preparation of androstane carbothiolates, such as fluticasone propionate, which avoids column chroma...
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JP3984315B2 |
The invention relates to a method of the preparation of a steroid derivative ketal according to the general formula I: wherein R1 is CH3 or C2H5; R2 is OH; R3 is H, CH3; C IDENTICAL CH, CH2Hal,, or CH2CN; or R2 and R3 together are O; R4 ...
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JP3983796B2 |
This invention provides a simplified method for converting pregnan-3,20-dione compounds to 3 alpha -hydroxy,3 beta -substituted-pregnanes. By selective use of reagents the unprotected dione is converted chemoselectively and diastereosele...
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JP3977462B2 |
The invention relates to a 11-(substituted phenyl)-estra-4,9-diene derivative of formula I wherein A is a residue of a 5- or 6-membered ring containing 2 heteroatoms which are not connected to each other and independently selected from O...
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JP2007210994A |
To obtain a steroid compound of a kind having an anti-progestin effect and a pharmaceutical value, to provide a method for preparing the steroid compound, to obtain a pharmaceutical composition for treating diseases associated with proge...
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JP2007119500A |
To provide a method for producing 3β,5α,6β-trihydroxy-6α,17α-dimethylpregnan-20-one monomethanolate.The method for producing 3β,5α,6β-trihydroxy-6α,17α-dimethylpregnan-20-one monomethanolate comprises displacing the solvent of ...
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JP2007502801A |
The invention relates to Delta15-D-homosteroids of general formula (I) process for their production and pharmaceutical compositions that contain these compounds. The compounds of general formula I according to the invention have androgen...
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JP2006526002A |
The invention relates to dialkyltriazene-bearing estrogens and anti-estrogens that are suited for use as chemotherapeutic drugs for treating carcinomas of the sexual organs of humans and animals.
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JP3845482B2 |
To isomerize an equilin into a delta (8,9)-dehydroestrone easily convertible to a component of a composite estrogen composition for hormone exchange therapy, etc., by treating an equilin with ethylenediamine Li salt or Li amide. An equil...
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JP3839994B2 |
To obtain sterol-fatty acid esters and specific vitamins without practically applying an organic solvent by making an esterase act on a mixture comprising specific vitamins, sterols, fatty acids or the like to selectively form the sterol...
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JP2006524202A |
This invention relates to 8beta-vinyl-11beta-(omega-substituted)alkyl-estra-1,3,5(10)-
trienes of general formula I with ERbeta-antagonistic activity, process for their production, their intermediate products, pharmaceutical preparations...
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JP2006522078A |
Dehydro-epiandrosterone (DHEA) derivatives (I) are new. Dehydro-epiandrosterone (DHEA) derivatives (A) are new. [Image] n : 1 or 2; R 1, R 2oxo or -O-W-O-; W : 2-8C linear, branched, cyclic, saturated or unsaturated alkyl (preferably CH ...
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JP3814312B2 |
PURPOSE: To obtain the subject new derivative having anti-glucocorticoid activity and usable in treating or preventing glucocorticoid-dependent diseases such as diabetes, hypertension and arteriosclerosis. CONSTITUTION: This new 11,12-bi...
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JP2006518715A |
The invention relates to the production and use of novel 14beta-alkyl-18-norsteroids, 8alpha,14beta-dialkyl-18-norsteroids, spiro[cyclopentano-perhydronaphthalin]-3,1'-pentanes or hexanes in addition to 14beta-fluoro-15beta,17beta-dihydr...
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JP2006518335A |
The disclosed invention refers to a process for obtaining fatty acid alkyl esters, rosin acids and sterols from crude tall oil (CTO), which is characterized by the following steps: (a) reacting the free fatty acids present in the CTO wit...
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JP3793087B2 |
The invention relates to the new 14,15-cyclopropanoandrosteroids of the 19-norandrostane series of the general formula (I)their synthesis and to pharmaceutical compositions containing these compounds.The compounds of formula (I) have an ...
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JP3793088B2 |
The invention relates to new unsaturated 14,15-cyclopropano-androstanes of the general formula (I) to their synthesis and to pharmaceutical compositions, containing these compounds. The compounds of formula (I) have gestagenic and/or and...
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JP2006151994A |
To provide a simple method for converting a pregnane-3,20-dione compound into a 3α-hydroxy-3β-substituted-pregnane.An unprotected dione is chemoselectively and stereoselelctively converted into a 3(R)-pregnane-3-spiro-2'-oxiran-20-one ...
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JP3776478B2 |
PURPOSE: To easily synthesize a coprostanediol derivative useful as a synthetic intermediate for a vitamin D derivative in large amount and high yield by a specific method using inexpensive lithocholic acid as a starting raw material. CO...
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JP3770904B2 |
PCT No. PCT/EP93/01606 Sec. 371 Date Apr. 18, 1995 Sec. 102(e) Date Apr. 18, 1995 PCT Filed Jun. 22, 1993 PCT Pub. No. WO94/04553 PCT Pub. Date Mar. 3, 1994.A process for the production of 1-methyl-3-keto- DELTA 1,4 steroids of general f...
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JP3764920B2 |
PURPOSE: To obtain a fluorine-containing steroid useful as a medicine, etc., in a high yield without using a gas difficult to handle by reacting a specific steroid with an electrophilic type fluorinating agent having nitrogen-fluorine bo...
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JP3759639B2 |
PURPOSE: To obtain a new 22-thiavitamin D3 derivative having strong suppressive activity against keratinocyte growth. CONSTITUTION: This is a compound of formula I (R1 is a 1-10C alkyl optionally substituted with ≥1 OH; R2 and R3 are e...
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JP3746292B2 |
PCT No. PCT/EP93/02207 Sec. 371 Date Feb. 27, 1995 Sec. 102(e) Date Feb. 27, 1995 PCT Filed Aug. 18, 1993 PCT Pub. No. WO94/00650 PCT Pub. Date May 17, 1994A process is provided for simultaneously recovering tocopherol and sterol from a ...
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JP3746174B2 |
Mometasone 17- furoate is made by direct esterification of the 17- hydroxyl group of mometasone using 2-furoyl chloride in the presence of a tertiary amine and an inert solvent, without prior protection of the free 11-hydroxy function.
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JP2006502172A |
There is provided a crystalline chemical composition comprising a compound of formula (I) in which the crystal lattice is stabilised by the presence of a guest molecule, characterised in the crystalline composition is of space group P212...
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