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Matches 1 - 50 out of 22,655

Document Document Title
WO/2024/037531A1
Provided are an anti-PSMA single-chain antibody, a chimeric antigen receptor associated therewith and use thereof. An amino acid sequence of a heavy chain of the anti-PSMA single-chain antibody includes a sequence shown in SEQ ID NO: 1, ...  
WO/2024/039683A1
Compositions and methods for therapeutic use of engineered myeloid cells are described. Methods for increasing therapeutic effectiveness of immune cells by use of an immune cell inhibitory agent prior to therapy is described. Effective u...  
WO/2024/037322A1
Disclosed in the present invention are an IL-15 mutant-Fc/IL-15Rα subunit-Fc heterodimer and the use thereof. The heterodimeric protein comprises protein a and protein b, wherein the protein a comprises an IL-15 mutant and a first Fc mu...  
WO/2024/038809A1
This fusion protein contains a plurality of receptor binding domains from parvovirus, wherein each receptor binding domain is tandemly linked with another such receptor binding domain, either directly or via a peptide linker.  
WO/2024/038447A1
The present invention provides a chimeric polynucleotide comprising: a first nucleic acid sequence encoding a first polypeptide selected from: alpha S 1 casein, alpha S2 casein, and beta casein, a whey polypeptide, or a functional analog...  
WO/2024/037477A1
The present invention relates to a bispecific chimeric antigen receptor, and an immune cell, a preparation method, an application and a tumor treatment drug. Provided is a bispecific chimeric antigen receptor, the chimeric antigen recept...  
WO/2024/037005A1
The present invention provides a human cytomegalovirus antigen epitope chimeric peptide and a use thereof. An amino acid sequence of the human cytomegalovirus antigen epitope chimeric peptide is selected from SEQ ID NO.1, SEQ ID NO.2, SE...  
WO/2024/034200A1
Disclosed are a highly rigid peptide linker inserted between a transmembrane protein and an organelle transport signal, a fusion protein containing the same, and a localization method that includes inserting a peptide linker.  
WO/2024/031187A1
There is provided a polynucleotide-modifying enzyme with a functional nuclease domain and a display domain. The functional nuclease domain comprises a nuclease catalytic pocket. The display domain comprises a peptidic recognition sequenc...  
WO/2024/031181A1
Breast cancer is now the most prevalent cancer worldwide, and despite therapeutical advances in the last decades, metastatic breast cancer remains an incurable disease. Novel tumor-specific antigens (TSAs) and tumor-associated antigens (...  
WO/2024/032454A1
Disclosed in the present invention is a long-acting abaloparatide compound. The long-acting compound of the present invention is used for preparing a pharmaceutical composition for treating diseases. Provided is a use of the pharmaceutic...  
WO/2024/032468A1
The present invention relates to the field of molecular vaccinology. Provided is a recombinant multi-component SARS-CoV-2 trimer protein vaccine capable of inducing broad-spectrum neutralization activity. The components of a recombinant ...  
WO/2024/033879A1
The present disclosure relates to modified cells, e.g., chimeric antigen receptor (CAR) T cells and/or exogenous T cell receptor (eTCR) cells, which have reduced in vivo immunogenicity, and the use thereof.  
WO/2024/006907A3
The current disclosure relates to, inter alia, compositions and methods, e.g., immunotherapies for cancer and autoimmunity. The present compositions comprise heterodimeric proteins comprising an alpha chain and a beta chain, each of the ...  
WO/2024/034619A1
According to an embodiment, the present disclosure provides a modified luciferase having improved luminescence intensity, and a use thereof. The present disclosure relates to a modified luciferase derived from a luminous mushroom, or a...  
WO/2024/032617A1
The present invention relates to a heteromultimeric protein and a preparation method therefor. Specifically, the heteromultimeric protein comprises a first antibody heavy chain with the introduction of a T394K mutation with respect to S3...  
WO/2024/027771A1
Provided in the present invention is an antibody fusion protein, which can specifically bind to an FAP protein and block a TGFβ signaling pathway. Further provided in the present invention are a nucleic acid molecule encoding the antibo...  
WO/2024/027835A1
Provided is an antibody targeting EGFRvIII or an antigen-binding fragment thereof. Further provided are a CAR comprising the antigen-binding fragment targeting EGFRvIII, and treatment and detection use thereof.  
WO/2024/006532A3
This disclosure provides self-assembling Ketol-acid reductoisomerase (KARI) nanoparticles that are capable of displaying multiple copies of antigens, antibodies and/or proteins or peptides on its surface; as well as nucleic acids encodin...  
WO/2024/030976A2
The disclosure relates to compositions and methods for the preparation, use, and/or formulation of active agents conjugated to ligands for increased crossing of the blood brain barrier.  
WO/2023/241023A3
Provided in the present invention is a novel phase-change adjusting kit, comprising at least two independent components which can interact with each other to specifically drive themselves and cell surface molecules combined thereon to ge...  
WO/2023/250384A3
The present disclosure provides CRISPR-Cas effector polypeptides that are referred to herein as "Cas12L" polypeptides, "Casλ" polypeptides, or "Cas-lambda" polypeptides. The present disclosure provides a nucleic acid encoding a Casλ po...  
WO/2024/027553A1
The present invention relates to the field of biomedicine, and particularly to a bifunctional fusion protein and the use thereof. The bifunctional fusion protein comprises an Fc fragment, wherein one end of the Fc fragment is connected w...  
WO/2023/240202A3
The present disclosure provides modified terminal deoxynucleotidyl (TdT) polymerases and compositions (e.g., conjugates) comprising modified TdT polymerases. The present disclosure also provides circularly permuted terminal deoxynucleoti...  
WO/2024/027223A1
The present invention provides an in vivo and in vitro editing preparation method for CAR-MΦ targeting tumor stem cells, and a use thereof. The invention provides a chimeric antigen receptor-macrophage (CAR-MΦ) and a nano-carrier based...  
WO/2024/022474A1
Provided is a chimeric transcriptional activator for a methanol-inducible promoter, which at least comprises a first portion and a second portion, wherein: 1) the first portion comprises: i) a DNA binding domain; or ii) a DNA binding dom...  
WO/2024/022384A1
An antibody-drug conjugate (ADC) especially PEG based bispecific antibody-drug conjugate (P-BsADC) comprises an antigen binding domain bonding to CD47 and PD-L1. A method for the preparation of the P-BsADC, a composition comprising the P...  
WO/2024/026465A1
Described in several example embodiments herein are engineered programmable pattern recognition compositions and uses thereof. In certain example embodiments, the engineered protein contains an NTPase of a Signal Transduction ATPases wit...  
WO/2024/022512A1
Provided are anti-Claudin-6 antibodies (e.g., VHH domain antibodies), and a chimeric antigen receptor (CAR) that binds to Claudin-6 comprising same in an extracellular antigen binding domain, a transmembrane domain, and an intracellular ...  
WO/2024/025435A1
The present invention relates to biotechnology and medicine, and more particularly to oncology, and can be used for treating tumours of different origins. Proposed is a hybrid protein molecule SRH-DR5-B containing at the N-terminus an an...  
WO/2024/024517A1
The present disclosure provides, inter alia, an enzyme electrode obtained by immobilizing an enzyme by using more appropriate binding. The enzyme electrode according to the present disclosure comprises an electrode and a modified protein...  
WO/2024/017362A1
Provided are a chimeric antigen receptor targeting GPRC5D and BCMA, and a use thereof. Specifically, provided are nucleic acids encoding the chimeric antigen receptor targeting GPRC5D and BCMA, a corresponding chimeric antigen receptor, ...  
WO/2024/018865A1
The present disclosure provides a novel carrier peptide fragment having cell membrane permeability. The carrier peptide fragment disclosed herein comprises an amino acid sequence which satisfies one of the conditions: (i) the eighth and ...  
WO/2024/020388A1
Disclosed herein are formulations of small molecule GIP/GLP-1 dual receptor agonists and uses thereof.  
WO/2024/020596A1
Fusion proteins, comprising at least one single chain antibody fragment (scFV), and a cancer antigen or marker, or a fragment thereof are provided. The scFV is capable of selectively binding to a cytokine released by chimeric antigen rec...  
WO/2024/016740A1
Provided is a biosynthesis-based preparation method for a structural material of the human body. A polypeptide of the present application contains the structure of a C-terminal region of (repeating unit)n or (repeating unit)n-; the repea...  
WO/2024/020366A1
Disclosed herein are improved broad-spectrum nanozymes for targeting RNA. The disclosed nanozymes are synthesized using recombinant ribonuclease with site-specific cysteine-substituted mutations that can be covalently functionalized with...  
WO/2024/017383A1
Provided are an anti-MCT1 antibody and use thereof. The MCT1 antibody and a humanized antibody thereof have high neutralization activity and high selectivity, can efficiently block the function of MCT1, and show good therapeutic activity...  
WO/2024/019642A1
The invention relates to biotechnology and medicine, and more particularly to oncology, and can be used for treating tumours. Proposed is a hybrid protein structure containing at the N-terminus of a polypeptide chain a receptor-specific ...  
WO/2024/012578A1
A non-human animal expressing a human or chimeric TLR7 and/or TLR8 protein, and a usage method therefor.  
WO/2024/012495A1
A chimeric antigen receptor (CAR) specifically binding to a CD5 protein, comprising a CD5 binding domain, a transmembrane domain, a co-stimulatory domain, and an intracellular signaling domain. Further provided is an engineered immune ef...  
WO/2024/011360A1
The present disclosure relates to a survival stress-based screening system and a high-throughput screening device. Particularly, the present disclosure relates to a fusion protein composition, fusion proteins, a recombinant nucleic acid ...  
WO/2024/015920A1
Engineered or non-naturally occurring systems and compositions comprising novel Cas5- HNH and Cas8-HNH polypeptides are detailed herein. Also provided are methods and applications for the novel Cas5-HNH and Cas8-HNH polypeptides for repr...  
WO/2024/011946A1
Provided is a polypeptide dimer for the treatment of systemic sclerosis.  
WO/2024/014989A1
The inventions relate to a recombinant protein GBD-ActRIIB containing an ActRIIB receptor fragment and a glucan-binding domain GBD, a method for producing said recombinant protein, a preparation for increasing muscle mass in livestock an...  
WO/2024/015743A1
This disclosure provides for engineered T cell Receptors (TCRs), cells comprising the TCRs, and methods of making and using the TCRs. The current disclosure relates to TCRs that specifically recognize epitope(s) from tumor antigen VCY CT...  
WO/2024/012540A1
Disclosed are Schistosoma japonicum eggs and the ingredients of secretions and excretions thereof, comprising eggs, egg culture supernatant, egg secreted proteins, etc. (hereinafter referred to as "Schistosoma eggs and secretions and exc...  
WO/2024/008145A1
A novel Cas enzyme, which belongs to a novel type of Cas protein and has a broad application prospect.  
WO/2024/008039A1
A heterodimeric fusion protein and the use thereof. The heterodimeric fusion protein contains: a first heavy chain, which contains an Fc region and an immunomodulator fused to the Fc region; and a light chain and a second heavy chain, wh...  
WO/2024/007672A1
Provided are an anti-CD24 antibody or an antigen-binding fragment thereof, a nucleic acid molecule, a vector and a host cell encoding the antibody or the antigen-binding fragment thereof, a derivative of the antibody or the antigen-bindi...  

Matches 1 - 50 out of 22,655