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JPS5549832B2 |
A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulanic acid has the formula (I): (I) In addition to being a broad spectrum antibiotic of medium potency, clavu...
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JPS5548799B2 |
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JPS55156597A |
A process for the preparation of alpha -carboxy, 6, alpha -methoxy penicillin derivatives by the enzymatic hydrolysis of an esterified derivative. The process is for the preparation of a compound of formula (I): (I) wherein R represents ...
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JPS55156596A |
A process for the preparation of alpha -carboxy, 6, alpha -methoxy penicillin derivatives by the enzymatic hydrolysis of an esterified derivative. The process is for the preparation of a compound of formula (I): (I) wherein R represents ...
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JPS55144897A |
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JPS5535120B2 |
1479174 6-Aminopenicillanic acid 1-oxide and salts thereof SHIONOGI & CO Ltd 20 Sept 1974 [21 Sept 1973] 41120/74 Heading C2C 6-Aminopenicillanic acid 1-oxide or a salt thereof is obtained by subjecting a penicillin 1-oxide or salt there...
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JPS5535113B1 |
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JPS55114297A |
PURPOSE: An optically inactive β-lactam type antibiotic is acylated by the action of a specific microorganism to produce an optically active β-lactam type biotic. CONSTITUTION: The reaction between an acid of formula I (R is acyl group...
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JPS5571497A |
PURPOSE: To prepare amoxicillin directly, by using 6-aminopenicillanic acid and 5- (p-hydroxyphenyl)hydantoin in the presence of a culture of specific microorganisms or its treated one. CONSTITUTION: Microorganisms, e.g. Pseudomonas hyda...
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JPS5554899A |
PURPOSE: To prepare a novel antibiotic substance PS-3 containing a heptemic acid skeleton and having strong antibacterial activity, in high efficiency, by aerobically culturing Streptomyces sp. A271 strain in a nutrient medium. CONSTITUT...
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JPS5510238B2 |
6-Aminopenicillanic acid or its salt is prepared from a penicillin or its salt by the action of a fungus belonging to the genus Pseudofusarium or its mycelium preparation.
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JPS558159B1 |
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JPS548754B2 |
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JPS543955B1 |
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JPS543519B2 |
To chemically bind either impure or purified enzymes to polyurethane to produce insolubilized bound enzymes which are still enzymically active and which may be more stable than the original enzyme, and which can be reused without appreci...
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JPS5343597B1 |
1382255 Preparing aminopenicillins TAKEDA YAKUHIN KOGYO KK 29 Dec 1971 [25 Dec 1970] 60406/72 Heading C2C [Also in Division C3] Aminopenicillins having the Formula (I) wherein R is an optionally substituted 6- membered cyclic hydrocarbon...
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JPS53107483A |
A thienamycin-containing fermentation broth or solution is brought into contact with a liquid ion exchanger which is dissolved in an organic solvent and is insoluble in water. In this process, the antibiotic is transferred, by forward ex...
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JPS535185A |
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JPS533590A |
A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulanic acid has the formula (I): (I) In addition to being a broad spectrum antibiotic of medium potency, clavu...
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JPS5246957B2 |
A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulanic acid has the formula (I): (I) In addition to being a broad spectrum antibiotic of medium potency, clavu...
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JPS5247038B2 |
At least one acryloyl monomer is polymerized in an aqueous suspension containing a penicillin amidase-producing microorganism. The acryloyl monomers employed in the present invention include acryloylamide, N,N'-lower alkylene-bis-acryloy...
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JPS52110894A |
PURPOSE: Introduction of α-amino-p-hydroxyphenylacetyl group to the 6-NH2 group of 6-aminopenicillanic acid can be efficiently effected by the action of acylase produced by a specific species of Microbaxterium.
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JPS52110895A |
PURPOSE: Introduction of D-α-amino-p-hydroxyphenylacetyl radical to the 6-NH2 group of 6-amino-penicillanic acid can be efficiently effected by the action of acylase producted by a specific species of Achromobacter, Bacillus, or Beneckea.
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JPS5296794A |
PURPOSE: To prepare 6-aminopenicillanic acid in high yield by reacting microorganisms of specific penicillinacylase-producing fungi with penicillins or their salts.
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JPS5214318B2 |
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JPS521996B2 |
A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulanic acid has the formula (I): (I) In addition to being a broad spectrum antibiotic of medium potency, clavu...
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JPS5145677B2 |
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JPS5145678B1 |
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JPS51133488A |
PURPOSE: To obtain penicillins or cephalosporins, that are useful for medicines, antibacterials and other synthetic intermediates, by means of an irreversible reaction of amibe formation being different from the reaction occurred in the ...
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JPS51133294A |
PURPOSE: Penicillins and cephalosporins having hydantoin ring of formula I are new: [where A is a group represented by formula II (R is H, lower alkyl or trilower alkylsilyl, etc.) or a group represented by formula III (X is H, OH, lower...
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JPS51133293A |
PURPOSE: Penicillins and cephalosporins having hydantoin ring of formula I and their salts are new: [where A is a group represented by formula II (R is H, lower alkyl or trilower alkylsilyl, etc.) or a group represented by formula III ( ...
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JPS5142197B1 |
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JPS5142198B1 |
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JPS5198297A |
Deacylation of benzyl- and phenoxymethylpenicillin tetrazoles to produce 6-amino-2,2-dimethyl-3-(tetrazol-5-yl)penam by the use of selected deacylases. The process is useful in the purification of said penam which is a valuable synthetic...
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JPS5127753B1 |
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JPS5112715B1 |
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JPS5143781A |
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JPS517758B1 |
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JPS517756B1 |
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JPS517757B1 |
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JPS51200B1 |
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JPS50123867A |
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JPS5049493A |
1443390 6-Amino-penicillanic acid SHIONOGI & CO Ltd 27 Aug 1974 [3 Sept 1973] 37486/74 Heading C2C 6-Amino-penicillanic acid or a salt thereof is prepared by subjecting a penicillin or salt thereof to a penicillin-amidase selected from P...
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JPS5011476B1 |
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JPS5011475B1 |
A process for the selective production of alpha -amino-benzylpenicillin from 6-aminopenicillanic acid, functional derivatives thereof and acid addition salts thereof whereby the reaction takes place in the presence of an alpha -aminobenz...
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JPS5011477B1 |
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JPS502757B1 |
1,164,457. Esters of 6-aminopenicillanic acid; penicillins; cephalosporins. BRISTOL-MYERS CO. 22 July, 1966 [22 July, 1965], No. 33038/66. Headings C2A and C2C, The invention relates to activated esters of 6-aminopenicillanic acid of for...
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JPS502759B1 |
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JPS502758B1 |
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JPS4946918B1 |
1331959 Preparing 6-aminopenicillanic acid BIOCHEMIE GmbH 25 Nov 1970 [28 Nov 1969] 55981/70 Heading C2A [Also in Division C3] 6-Aminopenicillanic acid is prepared by treating a penicillin of formula or an alkali metal salt thereof, wher...
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