Title:
【発明の名称】ウェルシュ菌ワクチン
Document Type and Number:
Japanese Patent JP2000506386
Kind Code:
A
Abstract:
The present invention provides proteins for use in vaccines which are capable of inducing protective antibodies directed against C. perfringens epsilon toxin when administered to animals or man and thereby providing prophylaxis or therapy against infection by C. perfringens epsilon toxin. Particularly the present invention provides proteins which are based upon the mature toxin of the clostridium perfringensepsilon toxin gene, but which have a mutation such that the amino acid at position 106 is different to the wild-type sequence and their use in vaccine compositions.
Inventors:
Tate Ball, Lichyard William
Williamson, Ethel Diane
Hubbard, Helen Lewis
Oyston, Petra Claire Fualkhal
Pain, Dane William
Williamson, Ethel Diane
Hubbard, Helen Lewis
Oyston, Petra Claire Fualkhal
Pain, Dane William
Application Number:
JP53236197A
Publication Date:
May 30, 2000
Filing Date:
March 11, 1997
Export Citation:
Assignee:
United Kingdom
International Classes:
C12N15/09; A61K31/00; A61K39/08; A61P31/00; A61P31/04; C07K14/33; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/00; C12N15/31; A61K38/00; A61K39/00; C12R1/145; (IPC1-7): C12N15/09; A61P31/04; A61K39/08; C07K14/33; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)