Title:
【発明の名称】置換1,2,3,4―テトラヒドロナフタレン誘導体
Document Type and Number:
Japanese Patent JP2000506883
Kind Code:
A
Abstract:
New piperidinyl- or piperazinyl-substituted-1,2,3,4-tetrahydronaphthalene derivatives having the formulawhereinX is N or CH;Y is NR2CH2, CH2-NR2, NR2-CO, CO-NR2 or NR2SO2;R1 is H, C1-C6 alkyl or C3-C6 cycloalkyl;R3 is C1-C6 alkyl, C3-C6 cycloalkyl or (CH2)n-aryl,where aryl is phenyl or a heteroaromatic ring containing one or two heteroatoms selected from N, O and S and which may be mono- or di-substituted;n is 0-4;as (R)-enantiomer, (S)-enantiomer or a racemate in the form of the free base or a pharmaceutically acceptable salt or hydrate thereof; a pharmaceutical formulation containing the compounds, use of the compounds in the treatment of 5-hydroxytryptamine mediated disorders, processes for the preparation of the compounds and intermediates for the preparation of the compounds.
Inventors:
Bellui, Stephan
Florvear, Rennert
Ross, Svuante
Touloubeli, Set-Ulov
Florvear, Rennert
Ross, Svuante
Touloubeli, Set-Ulov
Application Number:
JP53341097A
Publication Date:
June 06, 2000
Filing Date:
March 20, 1997
Export Citation:
Assignee:
Astra Actie Borrag
International Classes:
A61K31/00; A61K31/445; A61K31/495; A61K31/496; A61K31/535; A61K31/5375; A61P9/00; A61P9/12; A61P25/00; A61P25/22; A61P25/24; A61P43/00; C07D295/12; C07D211/24; C07D211/26; C07D211/34; C07D241/00; C07D295/096; C07D295/135; C07D295/215; C07D295/22; (IPC1-7): C07D211/24; A61P9/12; A61P25/00; A61P25/22; A61P25/24; A61P43/00; A61K31/445; A61K31/495; A61K31/5375; C07D211/26; C07D295/12; C07D295/22
Attorney, Agent or Firm:
Chika Takagi (1 person outside)