Title:
【発明の名称】疎水性の立体配座制限的微細環境を提供する部分によって強化された重合フルオロホア
Document Type and Number:
Japanese Patent JP2000509412
Kind Code:
A
Abstract:
Fluorescent conjugates suitable for use in flow cytometry and other biological applications. The fluorescent conjugates comprise an antibody having a polymeric dye bound thereto. The polymeric dye is preferably enhanced by a hydrophobic and conformationally restrictive moiety either bound thereto or in close association therewith. The hydrophobic and conformationally restrictive moiety is preferably derived from a cyclodextrin. The polymeric dye comprises a polymeric entity having signal-generating groups, such as aminostyryl pyridinium dye residues attached thereto. The fluorescent conjugates exhibit exceptional stability characteristics and avoid many of the problems of energy transfer, bio-conjugability, and solubility.
Inventors:
Bayenarts, Christopher
Huff, Jeffrey Bee
Cornwell, Michael Jay
Tata, Benkata Seshijali Earl
Huff, Jeffrey Bee
Cornwell, Michael Jay
Tata, Benkata Seshijali Earl
Application Number:
JP52779397A
Publication Date:
July 25, 2000
Filing Date:
January 30, 1997
Export Citation:
Assignee:
Abbot Laboratories
International Classes:
C09B69/10; G01N21/78; G01N33/533; (IPC1-7): C09B69/10; G01N21/78; G01N33/533
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)