Title:
【発明の名称】医用ホルモテロールエアゾール製剤
Document Type and Number:
Japanese Patent JP2000513340
Kind Code:
A
Abstract:
A pharmaceutical suspension formulation suitable for aerosol administration having from 0.0025 to 0.1 %w/w of micronized Formoterol, or an acid addition salt thereof, from 0.1 to 5.0 % w/w ethanol, HFA 134a, HFA 227 or a mixture of HFA 227 and HFA 134a, and optionally a surfactant other than a monoacetylated or diacetylated monoglyceride, the formulation being further characterized in that it exhibits substantially no growth in particle size or change in crystal morphology of the drug over a prolonged period, is substantially and readily redispersible, and upon redispersion does not flocculate so quickly as to prevent reproducible dosing of the drug.
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Inventors:
Oliver, Martin, Jay.
Paring, Simon, Gee.
Jinx, Philip, A.
Jayswell, Scinder, Kay.
Paring, Simon, Gee.
Jinx, Philip, A.
Jayswell, Scinder, Kay.
Application Number:
JP50165698A
Publication Date:
October 10, 2000
Filing Date:
June 02, 1997
Export Citation:
Assignee:
Minnesota Mining and Manufacturing Company
International Classes:
A61K9/00; A61K31/167; A61K9/12; (IPC1-7): A61K31/135; A61K9/12; A61K31/00
Domestic Patent References:
| JPH07502275A | 1995-03-09 | |||
| JPH04327527A | 1992-11-17 | |||
| JPH06508149A | 1994-09-14 | |||
| JPH06511235A | 1994-12-15 | |||
| JPH06501700A | 1994-02-24 | |||
| JPH07502033A | 1995-03-02 | |||
| JPH07505381A | 1995-06-15 | |||
| JPH05508616A | 1993-12-02 |
Foreign References:
| WO1994017784A1 | 1994-08-18 |
Attorney, Agent or Firm:
Takashi Ishida (4 others)