Title:
【発明の名称】ヘモグロビン―ヒドロキシエチルスターチ結合体含有酸素運搬剤、その製造方法及びその血液代用剤等としての使用
Document Type and Number:
Japanese Patent JP2000514434
Kind Code:
A
Abstract:
PCT No. PCT/EP97/03527 Sec. 371 Date Jan. 6, 1999 Sec. 102(e) Date Jan. 6, 1999 PCT Filed Jul. 7, 1997 PCT Pub. No. WO98/01158 PCT Pub. Date Jan. 15, 1998The present invention relates to new oxygen transfer agents which comprise haemoglobin-hydroxyethylstarch conjugates, and processes for their preparation. The invention furthermore relates to the use of the oxygen transfer agents as a blood substitute, plasma expander, perfusion agent, haemodilution agent and/or cardioplegic solution. The invention relates in particular to oxygen transfer agents which comprise a haemoglobin-hydroxyethylstarch conjugate in which the haemoglobin and the hydroxyethylstarch are linked to one another selectively via amide bonds between free amino groups of the haemoglobin and the reducing end group of the hydroxyethylstarch, which is present in oxidized form.
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Inventors:
Sommermeier, kraos
Eichner, Wolfram
Eichner, Wolfram
Application Number:
JP50476798A
Publication Date:
October 31, 2000
Filing Date:
July 07, 1997
Export Citation:
Assignee:
Fresenius AG
International Classes:
A61K38/00; A61K38/16; A61P7/08; C07K14/805; A61K47/48; (IPC1-7): A61K38/16; A61K38/00; A61K47/48; A61P7/08
Attorney, Agent or Firm:
Asato Kato