Title:
【発明の名称】システイン・プロテイナーゼ調節剤として有用な3,4―ジ置換アゼチジン―2―オン誘導体
Document Type and Number:
Japanese Patent JP2001503738
Kind Code:
A
Abstract:
The present invention is based on the discovery that certain 3,4-disubstituted-azetidin-2-one derivatives exhibit excellent cysteine proteinase inhibitory activity which can be used for treatment of different diseases such as muscular dystrophy, myocardial infarction, bone resorption, arthritis, cancer metastasis, pulmonary emphysema, septic shock, cerebral ischemia, memory function, Alzheimer and cataract, malaria, glomerular basement membrane degradation, bacterial infection, inflammatory diseases, parasitic infections, and viral infections. In accordance to the present invention, there is provided a 3,4-disubstituted-azetidin-2-one derivatives of formula I, wherein R1, R2 and R3 are as defined herein, or a pharmaceutically acceptable salt thereof.
Inventors:
Shin Rajeshwar
Zhou Nian Yi.
Guo Deki
Mikety Ronald G.
Zhou Nian Yi.
Guo Deki
Mikety Ronald G.
Application Number:
JP51444498A
Publication Date:
March 21, 2001
Filing Date:
September 22, 1997
Export Citation:
Assignee:
Sinfer Laboratories, Inc.
International Classes:
A61P3/00; A61P9/10; A61P11/00; A61P13/12; A61P19/02; A61P19/10; A61P21/00; A61P27/12; A61P29/00; A61P31/12; A61P33/00; A61P33/06; A61P35/04; A61K38/00; C07D205/085; C07D401/12; C07D403/12; C07D405/12; C07D409/12; C07D417/12; C07K5/08; (IPC1-7): C07K5/08; A61K38/00; A61P9/10; A61P11/00; A61P13/12; A61P19/02; A61P21/00; A61P27/12; A61P29/00; A61P31/12; A61P33/00; A61P35/04
Attorney, Agent or Firm:
Eiji Saegusa (9 others)