Title:
【発明の名称】ヒトスクアレンエポキシダーゼ
Document Type and Number:
Japanese Patent JP2001503985
Kind Code:
A
Abstract:
The present invention provides a human squalene epoxidase (HSQEP) and polynucleotides which identify and encode HSQEP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HSQEP and a method for producing HSQEP. The invention also provides for the use of HSQEP and agonists, antibodies, or antagonists specifically binding HSQEP, in the prevention and treatment of diseases associated with expression of HSQEP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HSQEP for the treatment of diseases associated with the expression of HSQEP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HSQEP.
Inventors:
Hillman, Jennifer El
Hawkins, Philip Earl
Hawkins, Philip Earl
Application Number:
JP52187598A
Publication Date:
March 27, 2001
Filing Date:
November 05, 1997
Export Citation:
Assignee:
INCYTE PHARMACEUTICALS INC.
International Classes:
A61K31/7088; A61K38/44; A61K39/395; A61K45/00; A61K48/00; A61P3/06; A61P9/10; A61P43/00; C07K16/40; C12N1/15; C12N1/19; C12N1/21; C12N5/10; G01N33/53; C12N9/02; C12N15/09; C12N15/53; C12Q1/68; G01N33/566; A61K38/00; (IPC1-7): C12N15/09; A61K31/7088; A61K38/44; A61K39/395; A61K45/00; A61P3/06; A61P9/10; A61P43/00; C07K16/40; C12N1/15; C12N5/10; C12N9/02; C12Q1/68; G01N33/53
Attorney, Agent or Firm:
Youichi Oshima