【発明の名称】タキサン類の選択的誘導体化法

Title:

【発明の名称】タキサン類の選択的誘導体化法

Document Type and Number:

Japanese Patent JP2001504864

Kind Code:

A

Abstract:

A process is described for converting the C(7) hydroxy group of a 10-acyloxy-7-hydroxytaxane to an acetal or ketal, the process comprising treating the 10-acyloxy-7-hydroxytaxane with a ketalizing agent in the presence of an acid catalyst to form a C(7) ketalized taxane of the formula or wherein either X³¹ or X³² represents the 10-acyloxy-7-hydroxytaxane moiety and the other of X³¹ and X³² as well as X³³ and X³⁴ are independently hydrocarbyl, substituted hydrocarbyl or heteroaryl moieties. Taxanes having a ketalized C(7) hydroxy group are also described.

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Inventors:

Holton, Robert A.
Zan, Zumin
Clark, Paul A

Application Number:

JP51349899A

Publication Date:

April 10, 2001

Filing Date:

August 17, 1998

Export Citation:

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Assignee:

Florida State University

International Classes:

C07D305/14; C07F7/18; C07D; C07F; (IPC1-7): C07D305/14

Attorney, Agent or Firm:

Aoyama Ryo (1 person outside)

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