Title:
【発明の名称】組織型プラスミノーゲンアクチベーター(t―PA)の変異体:組成物およびその使用方法
Document Type and Number:
Japanese Patent JP2001505765
Kind Code:
A
Abstract:
Variants of tissue plasminogen factor exhibit significantly enhanced fibrin stimulation, dramatically increased discrimination among fibrin co-factors, marked resistance to inhibition by PAI-1, and substantially increased zymogenicity, a combination of properties that enhance the therapeutic utility of the enzyme.
Inventors:
Madison, Edwin Elle.
Application Number:
JP52266198A
Publication Date:
May 08, 2001
Filing Date:
November 12, 1997
Export Citation:
Assignee:
The Script Research Institute
International Classes:
G01N33/53; C12N5/10; C12N9/64; C12N9/72; C12N15/09; C12Q1/68; A61K38/00; C12R1/91; (IPC1-7): C12N15/09; C12N5/10; C12N9/64; C12Q1/68; G01N33/53
Attorney, Agent or Firm:
Hidekazu Miyoshi (1 outside)
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