Title:
【発明の名称】CCR5受容体リガンド、抗炎症薬および抗-ウイルス薬としての置換ビス-アクリジンおよび関連化合物
Document Type and Number:
Japanese Patent JP2001509152
Kind Code:
A
Abstract:
This invention relates to substituted bis-acridines and related compounds which are ligands, in particular, antagonists of the CCR5 receptor. In addition, this invention relates to the treatment and prevention of disease states mediated by CCR5, including, but not limited to, asthma and atopic disorders, rheumatoid arthritis, atherosclerosis, psoriasis, auto immune diseases such as multiple sclerosis, and inflammatory bowel disease, all in mammals, by the use of substituted bis-acridines and related compounds which are CCR5 receptor antagonists. Also, since CCR5 is a co-receptor for the entry of HIV into cells, selective receptor ligands may be useful in the treatment of HIV infection.
Inventors:
Bondel, William Yee
Leader, Valerie A
Ku, Thomas Wen Hu
Leader, Valerie A
Ku, Thomas Wen Hu
Application Number:
JP53117498A
Publication Date:
July 10, 2001
Filing Date:
January 08, 1998
Export Citation:
Assignee:
SMITHKLINE BEECHAM CORPORATION
International Classes:
C07D219/02; A61K31/015; A61K31/03; A61K31/09; A61K31/473; A61K31/496; A61P1/04; A61P9/10; A61P11/06; A61P17/00; A61P17/06; A61P29/00; A61P31/18; A61P37/06; A61P37/08; C07D219/04; C07D219/06; C07D219/12; (IPC1-7): A61K31/015; A61P1/04; A61P9/10; A61P11/06; A61P17/00; A61P29/00; A61P31/18; A61P37/06; C07D219/02
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)