Title:
【発明の名称】ファルネシルプロテイントランスフェラーゼの阻害剤
Document Type and Number:
Japanese Patent JP2001509156
Kind Code:
A
Abstract:
The present invention relates to inhibitors of ras farnesylation of Formula (1), wherein T is of Formula (1) or (2) or (3), A is aryl or heteroaryl; B is aryl or heteroaryl; X and Y represent hydrogen, or both X and Y can represent a single bond (so as to form a double bond); R<1 >represents a group of Formula (II) or (III), the group of Formula (II) or Formula (III) (having L or D configuration at the chiral alpha carbon in the corresponding free amino acid); R<2 >represents hydrogen, aryl or heteroaryl; Z represents a direct bond, methylene, ethylene, vinylene, oxy, -CH2-O- or -O-CH2-; and R<3>-R<4>, p and r are as defined in the specification or a pharmaceutically-acceptable salt, prodrug or solvate thereof. Processes for their preparation, their use as therapeutic agents and pharmaceutical compositions containing them. A particular use is in cancer therapy.
Inventors:
Arnoul, Jean-Claude
Boyle, Francis Thomas
Gareth Morse, Davis
Wardworth, James Michael
Boyle, Francis Thomas
Gareth Morse, Davis
Wardworth, James Michael
Application Number:
JP53174798A
Publication Date:
July 10, 2001
Filing Date:
January 27, 1998
Export Citation:
Assignee:
Zeneca Limited
Zeneca-Pharma Societe Anonym
Zeneca-Pharma Societe Anonym
International Classes:
A61K31/415; A61K31/4168; A61K31/4178; A61K31/427; C07D233/60; A61K31/4439; A61K31/454; A61K31/5377; C07D233/54; C07D233/61; C07D233/64; C07D401/10; C07D401/12; C07D409/12; C07D413/12; C07D417/06; C07D417/14; C07D521/00; (IPC1-7): C07D233/60; A61K31/4168; C07D401/10; C07D417/06
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)