Title:
【発明の名称】CC-1065およびデュオカルマイシンのイソ-CBIおよびイソ-CI類似体
Document Type and Number:
Japanese Patent JP2001519412
Kind Code:
A
Abstract:
A series of bioactive analogs of (+)-CC-1065 (1) and the duocarmycins 2 and 3 are synthesized. The bioactive analogs include either iso-CI or iso-CBI (6 and 7) as a DNA alkylation subunit. Conjugated to the DNA alkylating subunits are a variety of DNA binding subunits. The bioactive analogs maintain their DNA selectivity and display enhanced reactivity.
Inventors:
Bogger Dale El
Application Number:
JP2000515871A
Publication Date:
October 23, 2001
Filing Date:
October 14, 1998
Export Citation:
Assignee:
THE SCRIPPS RESEARCH INSTITUTE
International Classes:
A61K31/403; A61K31/404; A61P35/00; A61P43/00; C07D209/12; C07D209/42; C07D209/60; C07D209/70; C07D209/94; C07D487/04; (IPC1-7): C07D209/70; A61K31/403; A61P35/00; A61P43/00; C07D209/12; C07D209/94; C07D487/04
Attorney, Agent or Firm:
Minoru Nakamura (10 outside)