Title:
【発明の名称】ホスフェートによって鎖延長化された生分解性ポリマー、組成物、物品、並びにその製造及び使用方法
Document Type and Number:
Japanese Patent JP2001521561
Kind Code:
A
Abstract:
Biodegradable polymers are described comprising the recurring monomeric units shown in formula I or II: wherein X is -O- or -NR'-, where R' is H or alkyl; L is a branched or straight chain aliphatic group having from 1-20 carbon atoms; M1 and M2 are each independently (1) a branched or straight chain aliphatic group having from 1-20 carbon atoms; or (2) a branched or straight chain, oxy-, carboxy- or amino-aliphatic group having from 1-20 carbon atoms; Y is -O-, -S- or -NR'-, where E' is H or alkyl; R is H, alkyl, alkoxy, aryl, aryloxy, heterocyclic or heterocycloxy; the molar ratio of x:y is about 1; the molar ratio n:(x or y) is between about 200:1 and 1:200; and the molar ratio q:r is between about 1:99 and 99:1; wherein said biodegradable polymer is biocompatible before and upon biodegradat. Processes for preparing the polymers, compositions containing the polymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the polymers, are also described.
Inventors:
Hi-Kuan Mao
Tsong Tuao
James P English
Come W. Leong
Tsong Tuao
James P English
Come W. Leong
Application Number:
JP54194898A
Publication Date:
November 06, 2001
Filing Date:
April 02, 1998
Export Citation:
Assignee:
Guildford Pharmaceuticals Inc.
Johns Hopkins University School of Medicine
Johns Hopkins University School of Medicine
International Classes:
A61K9/00; A61K9/16; A61L17/10; A61L17/12; A61L24/00; A61L26/00; A61L27/14; A61L27/18; A61L27/00; C08G63/692; C08G63/91; C08G69/42; C08G79/04; C08L67/00; C08L77/00; C08L85/02; C08L101/16; (IPC1-7): C08G79/04; A61L24/00; A61L27/00; C08G63/692; C08G69/42; C08L67/00; C08L77/00; C08L85/02
Attorney, Agent or Firm:
Masahiro Tanaka