Title:
【発明の名称】H3レセプターアンタゴニストとしてのフェニル-アルキル-イミダゾール
Document Type and Number:
Japanese Patent JP2001522836
Kind Code:
A
Abstract:
Disclosed are novel phenyl-alkyl-imidazoles of formula (I) wherein R<1>, R<7>, m, n, p, q, X, Y, Z, R and R<15> are as defined in the specification. Also disclosed are pharmaceutical compositions comprising the compounds of formula (I). Further disclosed are methods of treating allergy, inflammation, hypotension, glaucoma, sleeping disorders, states of hyper and hypo motility of the gastrointestinal tract, hypo and hyperactivity of the central nervous system, Alzheimer's, schizophrenia, obesity and migraines by administering compounds of formula (I). Also disclosed are methods for treatment of upper airway allergic responses comprising administering a compound, or salt or solvate thereof, of formula (I) in combination or admixture with a histamine H1 receptor antagonist.
Inventors:
Aslanian, Robert G.
McCormick, Kevin Dee.
Piwinski, John Jay.
McCormick, Kevin Dee.
Piwinski, John Jay.
Application Number:
JP2000520420A
Publication Date:
November 20, 2001
Filing Date:
November 05, 1998
Export Citation:
Assignee:
Schering Corporation
International Classes:
A61K31/4164; A61K31/4178; A61K31/4184; A61K31/4427; A61K31/443; A61K31/4433; A61K31/4439; A61K31/445; A61K31/495; A61P1/04; A61P3/04; A61P9/00; A61P9/02; A61P25/00; A61P25/06; A61P25/18; A61P25/20; A61P25/28; A61P27/06; A61P29/00; A61P37/08; A61P43/00; C07D233/54; C07D233/64; C07D401/12; C07D403/12; C07D405/12; C07D409/12; (IPC1-7): C07D233/64; A61K31/4164; A61K31/4178; A61K31/4184; A61K31/4439; A61P1/04; A61P3/04; A61P9/00; A61P9/02; A61P25/00; A61P25/06; A61P25/18; A61P25/20; A61P25/28; A61P27/06; A61P29/00; A61P37/08; A61P43/00; C07D401/12; C07D403/12; C07D405/12; C07D409/12
Attorney, Agent or Firm:
Shusaku Yamamoto