Title:
【発明の名称】NGF変異体
Document Type and Number:
Japanese Patent JP2001527402
Kind Code:
A
Abstract:
NGF variants which have trkC-binding activity and trkC-signal inducing activity are provided. The variants optionally have trkA or trkB binding and signal induction activity. The NGF variants of the present invention are useful in the treatment of neuronal disorders. Nucleic acids and expression vectors encoding the NGF variant neurotrophins are also provided.
Inventors:
Presta, Leona Dosey
Wolfer, roman
Winslow, John W
Wolfer, roman
Winslow, John W
Application Number:
JP54714498A
Publication Date:
December 25, 2001
Filing Date:
April 23, 1998
Export Citation:
Assignee:
Genentech, Incorporated
International Classes:
A61K38/22; A61P25/00; C07K14/48; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/18; C12P21/02; C12N15/09; A61K38/00; C12R1/91; (IPC1-7): C12N15/09; A61K38/22; A61P25/00; C07K14/48; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02
Attorney, Agent or Firm:
Masatake Shiga (8 outside)