Title:
【発明の名称】非ペプチドGnRH因子
Document Type and Number:
Japanese Patent JP2002505318
Kind Code:
A
Abstract:
Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are of the following general formula, where X1, X2, Y, and are defined variables:Such compounds and their pharmaceutically acceptable salts, multimers, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression of gonadotropin release is indicated. Methods for synthesizing the compounds and intermediates useful in their preparation are also described.
Inventors:
Mark Anderson
Alexander Polinski
Yufen Hong
Brad Gregor
Alexander Polinski
Yufen Hong
Brad Gregor
Application Number:
JP2000534531A
Publication Date:
February 19, 2002
Filing Date:
March 01, 1999
Export Citation:
Assignee:
Agoron Pharmaceuticals Incorporated
International Classes:
C07D237/24; A61K31/155; A61K31/357; A61K31/36; A61K31/381; A61K31/403; A61K31/4035; A61K31/404; A61K31/42; A61K31/4375; A61K31/4402; A61K31/443; A61K31/4433; A61K31/4709; A61P15/00; A61P35/00; A61P43/00; C07C279/12; C07D207/34; C07D209/42; C07D209/48; C07D213/70; C07D213/82; C07D213/85; C07D215/12; C07D231/14; C07D231/16; C07D261/10; C07D261/18; C07D307/00; C07D307/68; C07D307/71; C07D307/77; C07D307/91; C07D317/58; C07D317/62; C07D317/68; C07D319/18; C07D333/20; C07D333/34; C07D333/38; C07D333/40; C07D333/70; C07D405/12; C07D407/12; C07D409/12; C07D455/04; (IPC1-7): C07C279/12; A61K31/155; A61K31/357; A61K31/36; A61K31/381; A61K31/4035; A61K31/42; A61K31/4375; A61K31/443; A61K31/4433; A61K31/4709; A61P15/00; A61P35/00; A61P43/00; C07D209/42; C07D209/48; C07D213/70; C07D213/82; C07D213/85; C07D215/12; C07D237/24; C07D261/18; C07D307/77; C07D317/58; C07D317/62; C07D319/18; C07D333/20; C07D333/34; C07D333/40; C07D333/70; C07D405/12; C07D407/12; C07D409/12; C07D455/04
Domestic Patent References:
| JPH09500110A | 1997-01-07 | |||
| JPH06509075A | 1994-10-13 | |||
| JPH11501329A | 1999-02-02 |
Foreign References:
| WO1997021703A1 | 1997-06-19 |
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)