Title:
【発明の名称】マトリックスメタロプロテイナーゼ遺伝子の発現を調節することにおける使用のための方法および組成物
Document Type and Number:
Japanese Patent JP2002505573
Kind Code:
A
Abstract:
The present invention relates to methods for identifying and selecting compositions useful in differentially modulating the expression of two or more mammalian genes, particularly matrix metalloproteinase (MMP) genes such as those encoding interstitial collagenase (and other genes comprising an AP1-binding site) and stromelysin-3 (and other genes comprising a retinoic acid response element (RARE)). In addition, the invention relates to methods of treating a mammal (such as a human) suffering from or predisposed to a physical disorder, using pharmaceutical compositions comprising the compositions identified or selected by the above-described methods. The methods of the present invention are useful in treating a variety of physical disorders in mammals including cancers (particularly carcinomas), inflammatory disorders, fibrotic disorders, ocular disorders and osteoporosis.
Inventors:
Basset pole
Angler, Patrick
Eric Guerin
Angler, Patrick
Eric Guerin
Application Number:
JP54637298A
Publication Date:
February 19, 2002
Filing Date:
April 24, 1998
Export Citation:
Assignee:
Institut National Dura Sant'E d'Eur Le Cheche Medical
Centr National Durelle Cherus Scientific
Universite Louis Pasteur
BRISTOL-MYERS SQUIBB COMPANY
Centr National Durelle Cherus Scientific
Universite Louis Pasteur
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
C12N15/09; A61K31/07; A61K31/196; A61K31/357; A61K45/00; A61K45/06; A61P9/10; A61P19/02; A61P19/10; A61P21/02; A61P27/02; A61P35/00; C12N9/64; C12Q1/68; C12Q1/6897; (IPC1-7): C12N15/09; A61K31/196; A61K45/00; A61P9/10; A61P19/02; A61P19/10; A61P21/02; A61P27/02; A61P35/00; C12N9/64; C12Q1/68
Attorney, Agent or Firm:
Shusaku Yamamoto