【発明の名称】細胞外ロイシンリッチ反復領域を有する新規な哺乳動物G-タンパク質共役型レセプター

Japanese Patent JP2002507406

A

Isolated nucleotide compositions and sequences are provided for LGR4, LGR5 and LGR7 genes. The nucleic acid compositions find use in identifying homologous or related genes; in identifying endogenous ligands for these receptors; in producing compositions that modulate the expression or function of its encoded protein; for gene therapy; mapping functional regions of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes.

Suay, Aaron Jay. W.
Su, Xu Yu
Lian, Shan-Gun
Bandale Specs, Petras Johannes

JP2000537903A

March 12, 2002

March 25, 1999

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Board of Trustees of the Leland Stanford Junior University
Akzo Novel N B

A01K67/027; C07K14/705; C07K14/72; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12N15/12; C12P21/08; (IPC1-7): C12N15/09; A01K67/027; C07K14/705; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/08

JPN5001012314, ＨＷＡＮＧ, ＧＥＮＯＭＩＣＳ, 19951231, Ｖ３０　１９９５年発行, Ｐ２９３−２９８
JPN6009022440, Ｌｉｅｗ　Ｃ．　Ｃ．，　ｅｔ　ａｌ．, "Ｇ４６７２　Ｆｅｔａｌ　ｈｅａｒｔ　Ｈｏｍｏ　ｓａｐｉｅｎｓ　ｃＤＮＡ　ｃｌｏｎｅ　Ｇ４６７２　５−　ｅｎｄ，　ｍＲＮＡ　ｓｅｑｕｅｎｃｅ", Ｄａｔａｂａｓｅ　ＤＤＢＪ／ＥＭＢＬ／ＧｅｎＢａｎｋ　［ｏｎｌｉｎｅ］，　Ａｃｃｅｓｓｉｏｎ　Ｎｏ．　Ｒ５８６９８．１, 1995
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JPN6009022443, Ｊ．　Ｂｉｏｌ．　Ｃｈｅｍ．, 1997, ２７２（２）, ｐ．１００２−１０１０
JPN6009022445, Ｂｉｏｃｈｅｍ．　Ｂｉｏｐｈｙｓ．　Ｒｅｓ．　Ｃｏｍｍｕｎ．, 1993, １９７（３）, ｐ．１０６２−１０６９
JPN6009022447, ＣＡＢＩＯＳ, 1996, １２（２）, ｐ．８９−９４
JPN5001012315, ＨＳＵ, ＭＯＬＥＣＵＬＡＲ　ＥＮＤＯＣＲＩＮＯＬＯＧＹ, 19981201, Ｖ１２Ｎ１２, Ｐ１８３０−１８４５

Shusaku Yamamoto

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