Title:
【発明の名称】ヒト患者における抗原提示細胞および抗腫瘍応答の増強法
Document Type and Number:
Japanese Patent JP2002510642
Kind Code:
A
Abstract:
The present invention provides methods for enhancing the development of APC from precursor cells by administering a combination of GM-CSF and IL-4. The precursor cells include: cells contained in peripheral blood, CD14<+> cells and precursors in bone marrow. Thus, administration of GM-CSF and IL-4 can be used as a form of cytokine immunotherapy. One embodiment of the present invention involves systemic administration of GM-CSF and IL-4. In this embodiment, APC are required to directly access tumor antigens as they exist in vivo within the patient. A further embodiment of the present invention involves co-administration of a tumor-associated or tumor-specific antigen, with GM-CSF and IL-4, to induce antigen-specific immunity mediated by APC. Yet another embodiment of the present invention describes systemic administration of GM-CSF and IL-4 to achieve reduced tumor burden.
Inventors:
Ross michael derik
Figlin robert alan
Kielcher Sylvia Marie
Gitritz Barbara Jennifer
Figlin robert alan
Kielcher Sylvia Marie
Gitritz Barbara Jennifer
Application Number:
JP2000542028A
Publication Date:
April 09, 2002
Filing Date:
April 02, 1999
Export Citation:
Assignee:
The Legends of the University of California
International Classes:
A61K48/00; A61K38/00; A61K38/20; A61K39/00; A61P35/00; A61P37/04; A61P43/00; (IPC1-7): A61K38/00; A61K48/00; A61P35/00; A61P37/04; A61P43/00
Attorney, Agent or Firm:
Shimizu Hatsushi (1 person outside)