Title:
【発明の名称】α1aアドレナリン受容体拮抗薬
Document Type and Number:
Japanese Patent JP2002511086
Kind Code:
A
Abstract:
This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as alpha 1a adrenergic receptor antagonists. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds are selective in their ability to relax smooth muscle tissue enriched in the alpha 1a receptor subtype without at the same time inducing hypotension. One such tissue is found surrounding the urethral lining. Therefore, one utility of the instant compounds is to provide acute relief to males suffering from benign prostatic hyperplasia, by permitting less hindered urine flow. Another utility of the instant compounds is provided by combination with a human 5-alpha reductase inhibitory compound, such that both acute and chronic relief from the effects of benign prostatic hyperplasia are achieved.
Inventors:
Pattern, Michael A.
Bock, Mark Gee
Nagalas Nam, Danaparan
Rug, balat
Won, Wy Sea
Bock, Mark Gee
Nagalas Nam, Danaparan
Rug, balat
Won, Wy Sea
Application Number:
JP50472099A
Publication Date:
April 09, 2002
Filing Date:
June 17, 1998
Export Citation:
Assignee:
Merck End Company, Inc.
Synaptic Pharmaceutical Co., Ltd.
Synaptic Pharmaceutical Co., Ltd.
International Classes:
C07D233/74; A61K31/277; A61K31/40; A61K31/4166; A61K31/421; A61K31/426; A61K31/428; A61K31/4439; A61K31/513; A61P13/08; A61P43/00; C07C255/46; C07C271/24; C07D207/24; C07D207/263; C07D207/36; C07D207/404; C07D263/20; C07D263/26; C07D275/06; C07D277/14; C07D413/12; C07D417/12; C07D487/04; C07D491/048; (IPC1-7): C07C255/46; A61K31/277; A61K31/40; A61K31/4166; A61K31/421; A61K31/426; A61K31/428; A61K31/4439; A61K31/513; A61P13/08; A61P43/00; C07C271/24; C07D207/24; C07D207/263; C07D207/36; C07D207/404; C07D233/74; C07D263/20; C07D275/06; C07D277/14; C07D413/12; C07D417/12; C07D487/04; C07D491/048
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)