Title:
【発明の名称】ロタウイルス感染治療用多価ポリマー
Document Type and Number:
Japanese Patent JP2002515081
Kind Code:
A
Abstract:
The present invention includes polymerizable monomers comprising a fucoside moiety. In one embodiment, the monomer has a polymerizable functional group, such as an olefinic bond, to which the fucoside moiety is attached by a spacer group, for example, an alkylene group, or an alkylene group wherein one or more carbon atoms are substituted by heteroatoms, such as oxygen, nitrogen or sulfur atoms. The present invention also includes polymers comprising one or more fucoside moieties, such as pendant fucoside moieties, which can inhibit or prevent rotavirus infection in a mammal. Such a polymer can comprise, for example, a monomer of the present invention. The polymer can be a homopolymer or a copolymer, and can have, for example, a polyacrylamide, polyacrylate or polystyrene backbone. In another embodiment, the present invention comprises a method for treating a rotavirus infection in a mammal, for example, a human, by administering to the mammal a therapeutically effective amount of a polymer comprising one or more glycoside moieties, such as pendant glycoside moieties. The glycoside moieties can be, for example, fucoside moieties or sialic acid moieties. The polymer can be a homopolyrner or a co-polymer. In one embodiment, the polymer is a copolymer comprising a glycoside-bearing monomer and a hydrophobic monomer. In another embodiment, the polymer to be administered comprises two or more different glycoside-bearing monomers.
Inventors:
Mandeville, W. Harry, The Third
Petersen, John S.
Gariga Pachi, Venkata Earl.
Ninan, Thomas X.
Petersen, John S.
Gariga Pachi, Venkata Earl.
Ninan, Thomas X.
Application Number:
JP53284397A
Publication Date:
May 21, 2002
Filing Date:
March 13, 1997
Export Citation:
Assignee:
Geltex Pharmaceuticals, Inc.
International Classes:
A61K31/785; A61P31/12; C07D309/10; C07H13/04; C07H15/04; C07H15/12; C07H15/14; C08F20/58; C07H5/06; C08F246/00; (IPC1-7): C08F20/58; A61K31/785; A61P31/12; C07D309/10; C07H5/06; C07H15/04; C07H15/12; C07H15/14
Attorney, Agent or Firm:
Yoshinori Hosoda