Title:
【発明の名称】遺伝子発現を変調する因子のスクリーニング方法
Document Type and Number:
Japanese Patent JP2002515730
Kind Code:
A
Abstract:
The invention describes a method of screening for factors that modulate gene expression, by detection of factors including factors that stimulate or inhibit cell growth, differentiation or proliferation, factors involved in one or more signal transduction pathways, or factors involved in protein-protein interactions. Identification of such factors that modulate gene expression is accomplished by detection of an intracellular event mediated by the factor. The intracellular event can be an increase or decrease in transcription or translational activities. Detection of the intracellular event is accomplished by any highly sensitive assay targeting a transcription or translation product, including, for example, a bDNA assay to the nascent transcript induced by the factor.
More Like This:
Inventors:
Sen, Huy
Williams, Lewis Tee.
Escobedo, Jamie
Williams, Lewis Tee.
Escobedo, Jamie
Application Number:
JP51589097A
Publication Date:
May 28, 2002
Filing Date:
October 11, 1996
Export Citation:
Assignee:
Chiron Corporation
International Classes:
C07K14/47; C07K14/475; C07K14/52; C07K14/575; C07K14/705; C12Q1/68; C12N15/09; (IPC1-7): C12N15/09; C07K14/47; C07K14/475; C07K14/52; C07K14/575; C07K14/705; C12Q1/68
Attorney, Agent or Firm:
Shusaku Yamamoto