Title:
【発明の名称】新規カリウムチャンネル薬剤およびそれらの用途
Document Type and Number:
Japanese Patent JP2002517466
Kind Code:
A
Abstract:
This invention relates to novel multibinding compounds that bind to potassium (K<+>) channels and modulate their activity. The compounds of this invention comprise 2-10 K<+> channel ligands covalently connected by a linker or linkers, wherein the ligands in their monovalent (i.e., unlinked) state bind to one or more types of K<+> channel. The manner of linking the ligands together is such that the multibinding agents thus formed demonstrate an increased biologic and/or therapeutic effect as compared to the same number of unlinked ligands made available for binding to the K<+> channel. The invention also relates to methods of using such compounds and to methods of preparing them. The compounds of this invention are particularly useful for treating diseases and conditions of mammals that are mediated by K<+> channels. Accordingly, this invention also relates to pharmaceutical compositions comprising a pharmaceutically acceptable excipient and an effective amount of a compound of this invention.
Inventors:
Jacobsen, John Earl.
Eastman, Donna
Griffin, John H.
Eastman, Donna
Griffin, John H.
Application Number:
JP2000553118A
Publication Date:
June 18, 2002
Filing Date:
June 07, 1999
Export Citation:
Assignee:
Advanced Medicine Incorporated
International Classes:
G01N33/50; A61K9/06; A61K31/18; A61K31/343; A61K31/395; A61K31/407; A61K31/4178; A61K31/4427; A61K31/443; A61K31/4545; A61K45/00; A61K47/48; A61P9/00; A61P43/00; C07C311/08; C07C311/10; C07C311/12; C07C311/22; C07C311/30; C07D257/02; C07D307/80; C07D401/06; C07D405/12; C07D487/04; C07D487/08; C07K5/09; C07K5/11; C07K7/06; C07K7/08; G01N33/15; G01N33/566; G01N33/68; (IPC1-7): C07C311/08; A61K9/06; A61K31/18; A61K31/343; A61K31/395; A61K31/407; A61K31/4178; A61K31/4545; A61K45/00; A61K47/48; A61P9/00; A61P43/00; C07C311/10; C07C311/12; C07C311/22; C07C311/30; C07D257/02; C07D307/80; C07D401/06; C07D405/12; C07D487/04; C07D487/08; G01N33/15; G01N33/50; G01N33/566
Attorney, Agent or Firm:
Shusaku Yamamoto