Title:
【発明の名称】ドーパミンD3受容体のモジュレーターとしてのテトラヒドロイソキノリン誘導体
Document Type and Number:
Japanese Patent JP2002517493
Kind Code:
A
Abstract:
Compounds of formula (I): wherein R<2> represents a hydrogen atom or a C1-4alkyl group; q is 1 or 2; A represents a group of formula (a) or (b) wherein T, U, V and Y independently represent CH or a nitrogen atom; R<5> is a group selected from: a hydrogen or halogen atom, cyano, C1-4alkyl or C1-4alkoxy group; s is 1 or 2. Ar<2> represents an optionally substituted phenyl ring or an optionally substituted 5- or 6-membered aromatic heterocyclic ring; and salts thereof. The compounds are useful for the treatment of conditions which require modulation of a dopamine receptor such as schizophrenia.
Inventors:
Clive Leslie Branch
Christopher Nobert Johnson
Jeffrey Stemp
Christopher Nobert Johnson
Jeffrey Stemp
Application Number:
JP2000553421A
Publication Date:
June 18, 2002
Filing Date:
June 01, 1999
Export Citation:
Assignee:
SmithKline Beecham Public Limited Company
International Classes:
C07D217/04; A61K31/472; A61K31/4725; A61K31/506; A61P25/00; A61P25/18; A61P43/00; C07D401/12; C07D405/12; (IPC1-7): C07D217/04; A61K31/4725; A61K31/506; A61P25/00; A61P25/18; A61P43/00; C07D401/12; C07D405/12
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)