Title:
【発明の名称】プレニル-タンパク質トランスフェラーゼの阻害剤
Document Type and Number:
Japanese Patent JP2002519428
Kind Code:
A
Abstract:
The present invention is directed to peptidomimetic piperazine-containing macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.
Inventors:
Dainsmore, Christopher Jay
Bergman, Jeffrey M
Graham, Samuel El
Nguyuien, JM El
Stellsker, The Rerald Y
Williams, Theresa M
Zartman, Sea Blair
Bergman, Jeffrey M
Graham, Samuel El
Nguyuien, JM El
Stellsker, The Rerald Y
Williams, Theresa M
Zartman, Sea Blair
Application Number:
JP2000558105A
Publication Date:
July 02, 2002
Filing Date:
June 29, 1999
Export Citation:
Assignee:
Merck End-Campany Inc.
International Classes:
A61K31/337; A61K31/4995; A61P9/00; A61P9/10; A61P13/12; A61P27/02; A61P31/10; A61P31/12; A61P31/14; A61P35/00; A61P43/00; C07D498/18; C07D498/22; (IPC1-7): C07D498/18; A61K31/337; A61K31/4995; A61P9/00; A61P9/10; A61P13/12; A61P27/02; A61P31/10; A61P31/12; A61P31/14; A61P35/00; A61P43/00; C07D498/22
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)