Title:
【発明の名称】新規なエルゴリンアミン誘導体及びその使用法
Document Type and Number:
Japanese Patent JP2002520411
Kind Code:
A
Abstract:
The invention relates to novel derivatives of ergoline of the general formula 1in which R1 together with the two adjacent N atoms is the residue of a diamine and R4 together with the two adjacent carbonyl groups is the residue of a dicarboxylic acid. R2, R3, R6, R7, R8 can be H or an organic radical. R7 and R8 are H or together are a bond.The compounds show a strong antihypertensive effect. These effects moreover occur after intravenous and enteral administration even at dosages in the region of a few mug/kg (body weight). The compounds can accordingly be used as pharmaceuticals for hypertensive diseases in human medicine.
Inventors:
Vilva Ralph
Hertle Albert
Grusa Erica
Grapley Suzanne
Tillikke Ralph
Hertle Albert
Grusa Erica
Grapley Suzanne
Tillikke Ralph
Application Number:
JP2000560124A
Publication Date:
July 09, 2002
Filing Date:
July 15, 1999
Export Citation:
Assignee:
Sibio Screening Gezel Shaft Mitt Beschlenktel Haftung
International Classes:
A61K31/48; A61K33/26; A61P9/00; A61P9/12; C07D457/02; C07F15/02; C07F17/02; (IPC1-7): C07D457/02; A61K31/48; A61K33/26; A61P9/00; A61P9/12; C07F15/02; C07F17/02
Attorney, Agent or Firm:
Takehisa Ito (1 outside)