Title:
【発明の名称】ニューロンの成長および伸長を刺激するための化合物、組成物、および方法
Document Type and Number:
Japanese Patent JP2002520413
Kind Code:
A
Abstract:
Compounds that inhibit the peptidyl-prolyl isomerase (rotamase) enzyme activity of the FK-506 binding protein (FKBP) and compositions comprising these compounds are described. The FKBP-inhibiting compounds have a bicyclic [3.3.1], [4.3.1] or polycyclic azaamide nucleus. Pharmaceutical compositions containing such compounds help stimulate the outgrowth of neurites in nerve cells and augmenting nerve regeneration. Methods of treating nerve cells with such compositions are useful to promote repair of neuronal damage caused by disease and physical trauma.
Inventors:
Shin Kato
Hiroshi Kawakami
Hiroki Tada
Lynton Maria Angelica
Kalish vincent
Tatlock John Howard
Villafranca J. Ernest
Hiroshi Kawakami
Hiroki Tada
Lynton Maria Angelica
Kalish vincent
Tatlock John Howard
Villafranca J. Ernest
Application Number:
JP2000560126A
Publication Date:
July 09, 2002
Filing Date:
July 15, 1999
Export Citation:
Assignee:
Agron Fa-Mash-Tecals Inco-Polated
International Classes:
A61K31/499; A61K31/4995; A61K31/551; A61P25/00; A61P25/16; A61P25/28; A61P43/00; C07D221/00; C07D223/00; C07D241/00; C07D243/00; C07D263/00; C07D471/08; C07D471/18; C07D498/18; C07D519/00; A61K; C07D; (IPC1-7): C07D471/08; A61K31/4995; A61K31/551; A61P25/00; A61P25/16; A61P25/28; A61P43/00; C07D471/18; C07D498/18; C07D519/00
Attorney, Agent or Firm:
Shimizu Hatsushi (1 person outside)