Title:
【発明の名称】哺乳類マロニルCoAデカルボキシラーゼの阻害剤、作用物質および拮抗物質を同定するための組成物および方法
Document Type and Number:
Japanese Patent JP2002522082
Kind Code:
A
Abstract:
The present invention relates to the area of fatty acid oxidation, generally to compositions and methods of identifying and testing fatty acid oxidation inhibitors, and in particular, compositions comprising a novel cardiac isoform of MCD, identified to be a key regulator of fatty acid oxidation in the heart. Additionally, nucleic acid sequences of malonyl CoA decarboxylase genes from the rat pancreas, heart and liver are described. Such sequences and derived products are useful in screening methods for identifying and testing agonists and antagonists of the MCD pathway.
Inventors:
Ropa Schuk, Gary Dee.
Dick, jason
Dick, jason
Application Number:
JP2000565145A
Publication Date:
July 23, 2002
Filing Date:
August 09, 1999
Export Citation:
Assignee:
The Governors of the University of Alberta
International Classes:
C12N15/09; C07K16/40; C12N9/88; C12N15/60; C12Q1/527; (IPC1-7): C12N15/09; C07K16/40; C12N9/88; C12Q1/527
Attorney, Agent or Firm:
Takashi Ishida (4 others)