Title:
【発明の名称】誘導的発現系
Document Type and Number:
Japanese Patent JP2002523106
Kind Code:
A
Abstract:
The invention concerns an inducible expression system using nucleotide sequences coding for a transcriptional activator of eukaryotic or viral origin and a recombinant adenoviral vector comprising a gene of interest placed under the control of a promoter inducible in trans by said transcriptional activator. The invention also concerns a recombinant adenoviral vector bearing a first expression cassette coding for a transcriptional activator and a second cassette bearing a gene of interest placed under the control of a promoter inducible in trans by said transcriptional activator. The invention further concerns an infectious viral particle, its preparation method, a eukaryotic cell and a pharmaceutical composition comprising such a vector or expression system as well as their use for therapeutic or prophylactic purposes.
Inventors:
Majid, Metari
Tania, Saul-Guth
Tania, Saul-Guth
Application Number:
JP2000567726A
Publication Date:
July 30, 2002
Filing Date:
August 27, 1999
Export Citation:
Assignee:
TRANSGENE S.A.
International Classes:
C12N15/09; A61K35/76; A61K38/00; A61K48/00; A61P3/10; A61P7/04; A61P9/00; A61P9/08; A61P31/00; A61P31/04; A61P31/12; A61P31/18; A61P35/00; A61P43/00; C12N1/15; C12N1/19; C12N5/10; C12N7/00; C12N15/861; (IPC1-7): C12N15/09; A61K48/00; A61P3/10; A61P7/04; A61P9/08; A61P31/00; A61P31/04; A61P31/18; A61P35/00; A61P43/00; C12N1/15; C12N1/19; C12N5/10; C12N7/00
Attorney, Agent or Firm:
Kenji Yoshitake (4 others)