Title:
【発明の名称】合成ポリアミドによるHER2/neuオンコジーン発現の調節
Document Type and Number:
Japanese Patent JP2002524501
Kind Code:
A
Abstract:
Methods and compositions comprising polyamides capable of binding the minor groove of double-stranded DNA are described for the inhibition or reduction or gene transcription and expression. The polyamides comprise at least four complementary pairs of aromatic carboxamide residues which are selected to specifically contact and/or bind to the nucleotide sequence of a double-stranded DNA target in the promoter region of the target gene. The methods, compositions, and polyamides are disclosed for the inhibition of oncogene transcription and expression as well as the treatment of cancer.
Inventors:
Durban, Peter
Gottesfeld, Joel Em.
Long, John Jay.
Gottesfeld, Joel Em.
Long, John Jay.
Application Number:
JP2000569793A
Publication Date:
August 06, 2002
Filing Date:
September 10, 1999
Export Citation:
Assignee:
THE SCRIPPS RESEARCH INSTITUTE
California Institute of Technology
California Institute of Technology
International Classes:
A61K31/785; A61K31/00; A61K31/4178; A61K38/00; A61P35/00; A61P43/00; C12N15/09; C12Q1/68; G01N33/15; G01N33/50; G01N33/566; (IPC1-7): A61K31/785; A61P35/00
Attorney, Agent or Firm:
Shusaku Yamamoto